BOLD response to direct thalamic stimulation reveals a functional connection between the medial thalamus and the anterior cingulate cortex in the rat

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Bai-Chung ShyuChen Chang

Abstract

Recent functional neuroimaging studies in humans and rodents have shown that the anterior cingulate cortex (ACC) is activated by painful stimuli, and plays an important role in the affective aspect of pain sensation. The aim of the present study was to develop a suitable stimulation method for direct activation of the brain in fMRI studies and to investigate the functional connectivity in the thalamo-cingulate pathway. In the first part of the study, tungsten, stainless steel, or glass-coated carbon fiber microelectrodes were implanted in the left medial thalamus (MT) of anesthetized rats, and T2*-weighted gradient-echo (GE) images were obtained in the sagittal plane on a 4.7 T system (Biospec BMT 47/40). Only the images obtained with the carbon fiber electrode were acceptable without a reduction of the signal-to-noise ratio (SNR) and image distortion. In the second part of the study, a series of two-slice GE images were acquired during electrical stimulation of the MT with the use of a carbon fiber electrode. A cross-correlation analysis showed that the signal intensities of activated areas in the ipsilateral ACC were significantly increased by about 4.5% during MT stimulation. Functional activation, as assessed by the distrib...Continue Reading

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Citations

Mar 15, 2006·IEEE Transactions on Bio-medical Engineering·Francisco M Martínez SantiestebanDavid J Anderson
Jan 12, 2007·Journal of Cognitive Neuroscience·Benjamin A ParrisTimothy L Hodgson
May 16, 2014·PloS One·Tzu-Hao Harry ChaoChen-Tung Yen
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Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeff F DunnG Campbell Teskey
Apr 7, 2007·Annals of the New York Academy of Sciences·Helene BenvenistePatrick R Hof
Jul 16, 2008·Brain Research·Hilary D WilsonPerry N Fuchs
Feb 22, 2005·Current Opinion in Biotechnology·J Michael TyszkaRussell E Jacobs
Jun 16, 2004·Journal of Neuroscience Methods·Bai-Chuang ShyuChen Chang
Jul 21, 2015·PloS One·Nathalie Van Den BergeRoel Van Holen
Apr 4, 2007·Physics in Medicine and Biology·Francisco M Martinez-SantiestebanDavid J Anderson
Aug 31, 2018·Neuronal Signaling·Raj Kumar
Jan 23, 2021·Physics in Medicine and Biology·Rohit NayakAzra Alizad

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