BOLD signal in the motor cortex shows a correlation with the blood volume of brain tumors

Journal of Magnetic Resonance Imaging : JMRI
Lutz LüdemannClaus Zimmer

Abstract

To investigate whether and how the blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) signal is modified by brain tumors. The BOLD signal depends on the perfusion, which in turn may be affected in the presence of a tumor. Some studies have demonstrated a reduced BOLD signal in the tumor-bearing hemisphere. The BOLD signal variation in the motor cortex area was studied with finger tapping in a brain tumor group and a control group. An a priori volume-of-interest (VOI)-based method was applied that allows quantification of the mean BOLD signal amplitude and extent of activated volume. BOLD signal amplitude and activated volume were correlated with the extent of edema, a mass effect on the central sulcus, tumor volume, distance of tumor to somatosensory cortex, and tumor blood volume. In the tumor group the ipsilateral activated volume was reduced by 21% (P = 0.025) and the mean signal amplitude was reduced by 16% (P = 0.004). The mean BOLD signal amplitude shows a significant correlation with the total intratumoral blood volume (P = 0.014). We concluded that the peritumoral perfusion was reduced resulting due to a tumor aspirating perfusion (steal phenomenon).

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Citations

Feb 17, 2010·Der Radiologe·C Stippich
Jan 31, 2013·Seminars in Neurology·Daniel A OrringerAlexandra J Golby
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Sonya G WangMirela V Simon
Apr 1, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mirela V SimonEmad N Eskandar
Dec 3, 2014·Neuroimaging Clinics of North America·Meredith GabrielAndrei I Holodny
Feb 2, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mirela V SimonEmad N Eskandar
Apr 4, 2009·Neurobiology of Aging·Michal Schnaider BeeriIsak Prohovnik
Aug 2, 2007·Zeitschrift für medizinische Physik·Lutz LüdemannClaus Zimmer
Jun 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Rebecca Rakow-PennerGary H Glover
Dec 18, 2013·Journal of Magnetic Resonance Imaging : JMRI·Domenico ZacàJay J Pillai
Sep 18, 2014·International Journal of Computer Assisted Radiology and Surgery·Jiangfen WuZhou Yu
Jul 12, 2007·Journal of Magnetic Resonance Imaging : JMRI·Tristan BarrettPeter L Choyke
Jun 22, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Xiao-xiong JiaHe-chun Xia

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