Bolus dose remifentanil and sufentanil blunting cardiovascular intubation responses in children: a randomized, double-blind comparison

European Journal of Anaesthesiology
X LiaoYan-ming Zhang

Abstract

The present randomized controlled study was designed to compare the efficacy of remifentanil 2 microg kg(-1) and sufentanil 0.2 microg kg(-1) by bolus injection on the cardiovascular response to intubation in healthy children. One hundred and five children, ASA 1-2 and scheduled for elective plastic surgery under general anaesthesia, were randomly divided into one of two study groups to receive the following treatments in a double-blind manner: remifentanil 2 microg kg(-1) (group R) and sufentanil 0.2 microg kg(-1) (group S). Blood pressure and heart rate (HR) were recorded before anaesthesia induction (baseline values), immediately before intubation (postinduction values), at intubation and every minute for 5 min after intubation. The percentage changes in systolic blood pressure (SBP) and HR relative to baseline values were calculated. The incidences of SBP and HR percentage changes of more than 30% of baseline values during the observation were recorded. As compared with baseline values, blood pressure and HR at intubation and their maximum values during the observation increased significantly in group S, but decreased significantly in group R. Blood pressure and HR at intubation and their maximum values during the observati...Continue Reading

References

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Citations

Sep 21, 2010·Paediatric Anaesthesia·Stefan Lundeberg, James A Roelofse
Jul 21, 2011·Fundamental & Clinical Pharmacology·Georgia FotopoulouTheodoros Xanthos
Jan 28, 2010·Paediatric Anaesthesia·Maria SammartinoNicola Continolo
Jul 21, 2020·International Journal of Clinical Pharmacy·Yi-Heng LiuMeng Deng

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