PMID: 9660204Jul 11, 1998Paper

Bolus intravenous infusion of amino acids or lipids does not stimulate gallbladder contraction in neonates on total parenteral nutrition

Journal of Pediatric Surgery
S PhelpsA Pierro

Abstract

Stimulation of gallbladder contraction in patients receiving total parenteral nutrition (TPN) may be beneficial in preventing cholestatic jaundice associated with TPN. Bolus intravenous administration of either amino acids or fat promotes gallbladder contraction in normal adult volunteers after a period of starvation. This phenomenon has not been investigated in patients receiving continuous TPN. The aim of this study was to test the hypothesis that bolus intravenous infusion of amino acids or fat produces gallbladder contraction in neonates receiving TPN. Twenty-eight studies of gallbladder contraction were performed in 18 neonates receiving continuous TPN (median weight, 2.3 kg; range, 1.3 to 7.3; gestational age, 37 weeks; range, 28 to 40; age, 6.5 days; range, 2 to 180). Different types of experiments were performed: (1) bolus intravenous infusion of amino acid or fat for 60 minutes at twice the normal infusion rate; (2) bolus intravenous infusion of amino acid or fat for 15 minutes at four times the normal infusion rate. Gallbladder volume was measured by real-time ultrasonography by a single investigator. Measurements were made before starting the bolus infusion and every 15 minutes for 1 hour. The volume of the gallbladd...Continue Reading

References

Jan 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·S Y de BoerC B Lamers
Nov 1, 1985·AJR. American Journal of Roentgenology·W J DoddsM K Kern
Mar 4, 1968·JAMA : the Journal of the American Medical Association·D W Wilmore, S J Dudrick
Mar 1, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·D H TeitelbaumM A Schork

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Citations

Oct 7, 2006·Current Opinion in Gastroenterology·P Kitchen, A Forbes
Jun 1, 1999·Current Opinion in Pediatrics·L A Amii, R L Moss
May 3, 2007·Gastroenterology Clinics of North America·Andrew Ukleja, Michelle M Romano

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