May 2, 1978

Bombesin, bombesin analogues, and related peptides: effects on thermoregulation

Biochemistry
J E Rivier, M R Brown

Abstract

The synthesis and biological evaluation on thermoregulation of 39 peptides related to bombesin (structural analogues or other naturally occurring peptides) are described. The bioassay system reported measures the ability of peptides injected intracisternally to lower body temperature of cold (4 degrees C) exposed rats. The most potent analogues of bombesin were those in which positions one to five (not included) were altered, indicating that the decapeptide C terminal was sufficient for full potency. Gln at the seventh position and Gly at the 11th position could be replaced by D-Gln and D-Ala (but not D-Pro or D-Phe), respectively, without any change in potency. Methionine at the 14 position could be replaced with its D isomer with retention of 10% biological activity. Any other alteration of the C terminus (deletions or free acid with the exception of the N-methylamide) drastically reduced the biological potency of those peptides. Among other naturally occurring peptides, alytesin was found to have 100% of bombesin potency whereas litorin, neurotensin, xenopsin, substance P, physalaemin, and eledoisin were found to be in the order of 10(4) times less potent. The shortest peptide found to have full biological activity is the oc...Continue Reading

  • References31
  • Citations107

References

  • References31
  • Citations107

Citations

Mentioned in this Paper

GRP gene
Bombesin Dihydrochloride
Cold Temperature
Structure-Activity Relationship
Neurotensin
Lower Body Structure
NTS gene
Polypeptides
Hypothalamic Substance P
TAC1 gene

About this Paper

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