PMID: 7539740Mar 1, 1995Paper

Bombesin down modulates pulmonary fibrosis elicited in mice by bleomycin

Experimental Lung Research
P F PiguetF Thomas

Abstract

The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as evidenced by immunohistochemistry. Administration of bombesin by an osmotic minipump implanted IP, at a rate of 6 micrograms/h, decreased the lung hydroxyproline evident 15 days after IV or IT administration of bleomycin. In contrast, antibombesin monoclonal antibody 2A11 (mAb) increased the lung hydroxyproline content after IT administration of bleomycin. In addition, the mortality of bleomycin-injected mice was increased by the anti-bombesin mAb. Bombesin administration induced an increase, and anti-bombesin mAb induced a decrease, in the number of macrophages recovered from the bronchoalveolar lavage. Administration of bombesin did not change the mRNA levels of TNF-alpha, TGF-beta, and PDGF, as seen on Northern blots made with the lung RNA. Pulmonary platelet trapping, which was increased by a bleomycin injection, was decreased by an infusion of bombesin as demonstrated by the distribution of 111In-labeled platele...Continue Reading

References

Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·M E SundayJ S Torday
Sep 1, 1989·The Journal of Experimental Medicine·P F PiguetP Vassalli
Feb 1, 1988·Journal of Leukocyte Biology·C J WiedermannD H Bowden
Jan 1, 1985·Experimental Lung Research·R DayS Lemaire
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E Rozengurt, J Sinnett-Smith
Dec 1, 1980·The American Journal of Anatomy·H Elias, D M Hyde
Jul 1, 1980·Analytical Biochemistry·G HuszarF Naftolin
Feb 1, 1993·The American Review of Respiratory Disease·P F PiguetG E Grau

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Citations

Aug 1, 1997·Molecular Pathology : MP·D N Männel, G E Grau
Aug 3, 2004·The Journal of Clinical Investigation·Roderick J PhillipsRobert M Strieter
Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M P KeaneR M Strieter

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