Bombesin Encapsulated in Long-Circulating pH-Sensitive Liposomes as a Radiotracer for Breast Tumor Identification

Journal of Biomedical Nanotechnology
André Luís Branco de BarrosValbert Nascimento Cardoso

Abstract

Bombesin (BBN) is a tetradecapeptide that binds specifically to gastrin-releasing peptide receptors in humans. These receptors are over-expressed in several forms of cancer; radiolabeled BBN could therefore be used to detect such cancers. However, the degradation of peptides is a critical issue in the development of tumor tracers. Liposomes can be used to overcome this problem and improve the uptake of tracers by tumors. Therefore, the purpose of this study was to prepare and characterize long-circulating and pH-sensitive liposomes (SpHL) containing 99mTc-HYNIC-βAla-Bombesin(7-14) (99mTc-BBN(7-14). In addition, the ability of this system to identify human breast cancer tissue was evaluated using biodistribution studies and scintigraphic images. Long-circulating and pH-sensitive liposomes (SpHL) were prepared and freeze-dried in the presence of cryoprotectants (glucose, mannitol, and trehalose). They were subsequently reconstituted with a solution of 99mTc-HYNIC-βAla-Bombesin(7-14) (99mTc-BBN(7-14)). The liposomes were evaluated for size, encapsulation percentage, radiotracer leakage, and storage stability. In addition, in vivo studies were performed in breast tumor-bearing nude mice. Liposomes in the presence of glucose (SpHLG)...Continue Reading

Citations

Nov 4, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Juliana O SilvaAndre Luis Branco de Barros
Mar 17, 2016·Expert Opinion on Therapeutic Targets·Paola MorenoRobert T Jensen
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Renata Salgado FernandesAndré Luis Branco de Barros
Feb 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liziane O F MonteiroAndré L B de Barros
Feb 7, 2018·Nanotechnology Reviews·Parham Sahandi ZangabadMichael R Hamblin
Oct 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jafrin Jobayer SonjuSeetharama D Jois
Mar 17, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ejaj AhmadSundeep Singh Saluja

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