Bombesin inhibits histamine release from the rat oxyntic mucosa by a somatostatin-dependent mechanism

Scandinavian Journal of Gastroenterology
A K SandvikH L Waldum

Abstract

This study examines the effect of bombesin on endogenous somatostatin and the histamine-synthesizing enterochromaffin-like cells. Somatostatin and histamine were measured in the venous effluent of isolated/antrectomized vascularly perfused rat stomachs after administration of bombesin and gastrin alone or combined. Histidine decarboxylase (HDC) enzyme activity and mRNA abundance were measured in the gastric corpus after intravenous administration of bombesin to conscious rats. Bombesin released somatostatin from the isolated stomachs and reduced basal and gastrin-stimulated venous histamine. Somatostatin antiserum partially reversed the effect of bombesin on basal and gastrin-stimulated histamine release. In conscious fed rats, intravenous bombesin doubled serum gastrin concentrations and increased HDC activity. We conclude that endogenous (paracrine) somatostatin inhibits basal and gastrin-stimulated histamine release from the ECL cell. In intact animals this effect is surmountable by simultaneously released gastrin, suggesting that a balance between the effects of gastrin and somatostatin determines the activation of the ECL cell.

References

Jul 1, 1991·The American Journal of Physiology·M K SpencerA Katz
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D R JosephC A Zahnow
Apr 1, 1986·Scandinavian Journal of Gastroenterology·P M KlevelandH L Waldum
Jan 1, 1981·Peptides·N YanaiharaT Iwanaga
Jun 1, 1993·The Journal of Physiology·R DimalineG J Dockray
Aug 1, 1993·The American Journal of Physiology·N M RahaP A Knauf

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Citations

Jun 1, 2001·Regulatory Peptides·C Dornonville de la CourR Håkanson
Oct 2, 2002·Molecular and Cellular Endocrinology·Ingunn BakkeHelge L Waldum
Apr 15, 2003·The Journal of Physiology·Laura PiquerasVicente Martínez
Dec 4, 2010·Journal of Biomedicine & Biotechnology·Reidar FossmarkHelge L Waldum
Aug 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tom C MartinsenHelge L Waldum

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