Bombesin-like peptide is present in duct cells in salivary glands: studies on normal and irradiated animals

Neuropeptides
Y AaltoS Forsgren

Abstract

Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid glands of rats was examined 10 days after 5 consecutive days with daily doses of 6-8 Gy irradiation. Radioimmunoassay (RIA) methods were also used. Immunoreactive granular structures were observed within duct cells of both controls and irradiated animals. In the parenchyma of irradiated animals, very few nerve fibres showing BN-like immunoreactivity were observed. The RIA analysis showed that the content of BN-like material significantly increased in submandibular and parotid glands in response to irradiation. The results suggest that mainly a non-neural form of BN is detected in the salivary glands in the immunohistochemical analysis. Thus, the immunohistochemical observations suggest that BN-like peptides may be present in the duct system, where they may be constituents of the saliva. The observations of an increase in BN content in response to irradiation are of interest as BN has mitogenic effects, may stimulate...Continue Reading

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Citations

Jan 30, 2002·Peptides·Federica AlboPaolo Rossi
Sep 20, 2001·International Immunopharmacology·F AlboP Rossi
Jul 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mirco SchapherMichael Gröschl
Jun 28, 2000·Archives of Oral Biology·M Marini, L G Roda
Oct 15, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph F PierreKenneth A Kudsk
Aug 4, 2009·Journal of Veterinary Pharmacology and Therapeutics·C Pedernera-RomanoC Cristòfol

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