Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism

American Journal of Physiology. Heart and Circulatory Physiology
Dalya M LateefMarc L Reitman

Abstract

Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor that regulates energy expenditure, food intake, and body weight. We examined the effects of BRS-3 deletion and activation on blood pressure and heart rate. In free-living, telemetered Brs3 null mice the resting heart rate was 10% lower than wild-type controls, while the resting mean arterial pressure was unchanged. During physical activity, the heart rate and blood pressure increased more in Brs3 null mice, reaching a similar heart rate and higher mean arterial pressure than control mice. When sympathetic input was blocked with propranolol, the heart rate of Brs3 null mice was unchanged, while the heart rate in control mice was reduced to the level of the null mice. The intrinsic heart rate, measured after both sympathetic and parasympathetic blockade, was similar in Brs3 null and control mice. Intravenous infusion of the BRS-3 agonist MK-5046 increased mean arterial pressure and heart rate in wild-type but not in Brs3 null mice, and this increase was blocked by pretreatment with clonidine, a sympatholytic, centrally acting α2-adrenergic agonist. In anesthetized mice, hypothalamic infusion of MK-5046 also increased both mean arterial pressure and heart rat...Continue Reading

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Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Xiangping QuRujiao Liu
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Jan 9, 2020·Archives of Medical Research·Mei LiHong Liu
Nov 26, 2021·Biochemical Pharmacology·Timothy D Bryson, Pamela Harding

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