Bombesin Receptor Gene Expression in Rat Embryos: Transient GRP-R Gene Expression in the Posterior Pituitary

Molecular and Cellular Neurosciences
E WadaS Wray

Abstract

Bombesin-like peptides can stimulate growth of cultured cells derived from ectoderm, endoderm, or mesenchyme and act as autocrine growth factors in some lung carcinoma cell lines. Recently, cDNA clones for two mammalian bombesin receptors (BN-R), gastrin-releasing peptide receptor (GRP-R) and neuromedin B receptor (NMB-R), were characterized and shown to be present in distinct regions of the central nervous system at birth. To determine whether the spatial and/or temporal expression of BN-R genes correlated with tissue-specific or organ-specific developmental events, the prenatal distribution of GRP-R and NMB-R mRNAs were compared by in situ hybridization histochemistry. The differential expression of these two BN-R genes was striking. From early embryonic stages, GRP-R mRNA was expressed in various organs, including nervous, urogenital, respiratory, and digestive systems. In contrast, NMB-R gene expression was detected at later embryonic stages and the distribution of expression was much more limited. In most tissues, after onset of expression, both receptor mRNAs showed a steady increase in expression throughout development. However, transient expression of GRP-R mRNA was seen in the posterior pituitary. Intense GRP-R labelin...Continue Reading

Citations

Oct 31, 1994·Annals of the New York Academy of Sciences·J BatteyS Wray
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·L L HamptonJ F Battey
Sep 1, 1995·Medicinal Research Reviews·G S KroogJ F Battey
Oct 1, 1996·Endocrine Pathology·Mary E. Sunday
Nov 24, 1999·The American Journal of Physiology·R L EmanuelM E Sunday
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lin ShanMary E Sunday
May 14, 2004·American Journal of Physiology. Renal Physiology·Chelsea DumesnyArthur Shulkes
Jan 29, 2002·Biochemical and Biophysical Research Communications·Kumiko AokiEtsuko Wada
Jun 7, 2000·Progress in Neurobiology·H Ohki-Hamazaki

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