PMID: 8602736Mar 22, 1996Paper

Bombesin receptors in the brain

Annals of the New York Academy of Sciences
G N WoodruffR D Pinnock

Abstract

We have shown that in the central nervous system BN receptors are closely associated with 5-HT systems. On a subpopulation of dorsal raphe neurons, NMB receptors are able to depolarize cells by reducing gK+. In one of the target regions of the dorsal raphe 5-HT neurons, the SCN, we have also shown that neurons are excited by BN-related peptides. In the SCN, the GRP receptors excite neurons by two different mechanisms: closure of gK+ and opening of an unidentified cation conductance. Expression of human BN receptors from the brain in CHO cells or Xenopus oocytes shows a very similar pharmacological profile to that seen in the rat brain slice preparations. In the CHO cell line, following BN receptor activation, a major second-messenger path involves hydrolysis of PIP2 by phospholipases to yield IP3, which releases Ca2+ from intracellular stores. In the oocyte expression system, a similar second messenger pathway is clearly apparent, and Ca2+-sensitive gCl- represents the last phase in a cascade of events. The final phase of the mechanism of action in the artificial systems does not involve gK+, suggesting a different second messenger cascade to that in neurons. However, the involvement of phospholipases and their phospholipid pro...Continue Reading

References

Sep 12, 1979·Biochemical and Biophysical Research Communications·T J McDonaldV Mutt
Sep 1, 1992·European Journal of Biochemistry·V GorbulevF Fahrenholz
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F BatteyR I Feldman
Dec 1, 1991·Trends in Neurosciences·J Battey, E Wada
Jan 1, 1991·Annual Review of Pharmacology and Toxicology·G N Woodruff, J Hughes
Jan 1, 1988·Annals of the New York Academy of Sciences·T W MoodyJ M Rosenstein
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C D StraderR A Dixon
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S S KarnikH G Khorana
Jul 8, 1985·Brain Research·R D Pinnock
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E R SpindelJ F Habener
Jul 1, 1984·Peptides·G Falconieri ErspamerN Yanaihara
Jul 29, 1983·Biochemical and Biophysical Research Communications·N MinaminoH Matsuo
Apr 1, 1995·Trends in Biochemical Sciences·J IngleseR J Lefkowitz
Oct 1, 1994·Pflügers Archiv : European journal of physiology·G MealingJ L Schwartz
Jan 1, 1994·Annual Review of Biochemistry·C D StraderR A Dixon
Nov 1, 1993·Biochemical Society Transactions·R E Abayasekara, A P Flint
Jan 28, 1993·Nature·M J Berridge
Feb 1, 1993·Pflügers Archiv : European journal of physiology·R D Harvey

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Citations

Dec 8, 2000·European Journal of Pharmacology·S J BroughD Smart
Aug 19, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Branimir Zogovic, Paul M Pilowsky
Apr 4, 2006·Neuroscience and Behavioral Physiology·E N Glazkova, A N Inyushkin
Nov 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mary Ellen MaddalenaLaura E Lantry

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