Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America
Naoki YamanakaYoshiaki Tanaka

Abstract

Insect molting and metamorphosis are induced by steroid hormones named ecdysteroids, whose production is regulated by various neuropeptides. We cloned the gene and analyzed the expression of the prothoracicostatic peptide, a unique neuropeptide shown to suppress the production of ecdysteroids in the prothoracic gland of the silkworm, Bombyx mori. We also characterized a Bombyx G protein-coupled receptor, which has previously been identified as an ortholog of the Drosophila sex peptide receptor, as a functional prothoracicostatic peptide receptor. This receptor responded specifically to the prothoracicostatic peptides when examined using a heterologous expression system. The receptor was highly expressed in the prothoracic gland on the day before each larval and pupal ecdysis, when prothoracicostatic peptides are synthesized at a high level in the epiproctodeal glands. These results suggest that the sex peptide receptor functions as a prothoracicostatic peptide receptor in Bombyx and that the peripheral neurosecretory cells as well as the central neuroendocrine system play stage-specific roles in regulating ecdysteroidogenesis.

References

Feb 1, 1989·The Journal of Cell Biology·M Kozak
Aug 25, 1995·Nucleic Acids Research·S K Goda, N P Minton
Sep 8, 1995·The Journal of Biological Chemistry·M W LorenzK H Hoffmann
Jan 1, 1993·Archives of Insect Biochemistry and Physiology·E BuddJ Koolman
Oct 26, 1999·The Journal of Biological Chemistry·Y J HuaH Kataoka
Feb 17, 2001·Peptides·R PredelM Eckert
Oct 24, 2001·Archives of Insect Biochemistry and Physiology·M B BlackburnA K Raina
Dec 1, 2001·Annual Review of Entomology·Lawrence I GilbertJames T Warren
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoonseong ParkMichael E Adams
Oct 5, 2002·Science·Michael A RiehleMark R Brown
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kristoffer EgerodCornelis J P Grimmelikhuijzen
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tetsuro Shinoda, Kyo Itoyama
Oct 14, 2003·The Journal of Biological Chemistry·Erik C JohnsonPaul H Taghert
Nov 6, 2003·Insect Biochemistry and Molecular Biology·Keiko Takaki, Sho Sakurai
Feb 11, 2005·The Journal of Biological Chemistry·Naoki YamanakaHiroshi Kataoka
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Naoki YamanakaHiroshi Kataoka
Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Young-Joon KimMichael E Adams
Oct 28, 2006·Science·Amanda B HummonJonathan V Sweedler
Dec 28, 2006·Cell·Leonid L MorozEric R Kandel
Dec 7, 2007·Frontiers in Neuroendocrinology·Frank HauserCornelis J P Grimmelikhuijzen
Dec 7, 2007·Developmental Cell·Zofeyah McBrayerMichael B O'Connor
Mar 13, 2009·Insect Biochemistry and Molecular Biology·Ladislav RollerYoshiaki Tanaka

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Citations

Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Young-Joon KimBarry J Dickson
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Markus ConzelmannGáspár Jékely
Oct 4, 2013·Proceedings. Biological Sciences·Irmgard U HaussmannMatthias Soller
Jan 15, 2013·International Journal of Peptides·Xiaoguang LiuQingwen Zhang
Jan 21, 2011·BMC Neuroscience·Ling GanNingjia He
Oct 18, 2012·Annual Review of Entomology·Naoki YamanakaMichael B O'Connor
May 12, 2010·Cellular and Molecular Life Sciences : CMLS·Jeroen PoelsJozef Vanden Broeck
May 7, 2014·FEBS Letters·Sung-Hwan JungYoung-Joon Kim
Feb 21, 2016·Peptides·Ladislav RollerDušan Žitňan
Sep 18, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Umme SalmaHyun-Woo Kim
Dec 27, 2011·General and Comparative Endocrinology·Penny M Hopkins
Mar 24, 2011·Insect Biochemistry and Molecular Biology·Orly HaninAda Rafaeli
Nov 26, 2010·Peptides·Geoffrey M Coast, David A Schooley
Aug 6, 2010·Insect Biochemistry and Molecular Biology·Yi FanNaiming Zhou
Aug 1, 2015·Insect Biochemistry and Molecular Biology·Neil Audsley, Rachel E Down
Dec 18, 2010·The Journal of Comparative Neurology·Naoki YamanakaYoshiaki Tanaka
Aug 27, 2014·General and Comparative Endocrinology·Hans Peter VandersmissenJozef Vanden Broeck
May 20, 2015·Journal of Insect Physiology·Heleen VerlindenElisabeth Marchal
May 18, 2010·Current Biology : CB·Carlos Ribeiro, Barry J Dickson
Mar 5, 2013·General and Comparative Endocrinology·Hans Peter VandersmissenJozef Vanden Broeck
Nov 30, 2010·Biochemical and Biophysical Research Communications·Karina K HansenCornelis J P Grimmelikhuijzen
May 24, 2016·Journal of Insect Physiology·Sheila Ons
May 28, 2016·Fly·Manabu Tsuda, Toshiro Aigaki
Feb 6, 2016·Scientific Reports·Alexandros AlexandratosSkarlatos G Dedos
Jan 29, 2020·Journal of Evolutionary Biology·Meaghan K McGeary, Geoffrey D Findlay
Sep 1, 2017·Genome Biology and Evolution·Katina I SpanierStein Aerts
Jun 18, 2020·Frontiers in Endocrinology·Elizabeth A Williams
Oct 21, 2017·Scientific Reports·Surjeet Kumar AryaPraveen Chandra Verma
Mar 21, 2018·Journal of Chemical Ecology·Jean-Christophe Billeter, Mariana F Wolfner

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