Bone Adaptation in Adult Women Is Related to Loading Dose: A 12-Month Randomized Controlled Trial.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Karen L TroyTiffiny A Butler

Abstract

Although strong evidence exists that certain activities can increase bone density and structure in people, it is unclear what specific mechanical factors govern the response. This is important because understanding the effect of mechanical signals on bone could contribute to more effective osteoporosis prevention methods and efficient clinical trial design. The degree to which strain rate and magnitude govern bone adaptation in humans has never been prospectively tested. Here, we studied the effects of a voluntary upper extremity compressive loading task in healthy adult women during a 12-month prospective period. A total of 102 women age 21 to 40 years participated in one of two experiments: (i) low (n = 21) and high (n = 24) strain magnitude; or (ii) low (n = 21) and high (n = 20) strain rate. Control (n = 16) no intervention. Strains were assigned using subject-specific finite element models. Load cycles were recorded digitally. The primary outcome was change in ultradistal radius integral bone mineral content (iBMC), assessed with QCT. Interim time points and secondary outcomes were assessed with high resolution pQCT (HRpQCT) at the distal radius. Sixty-six participants completed the intervention, and interim data were anal...Continue Reading

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Citations

Aug 28, 2020·Journal of Biomechanical Engineering·Megan E Mancuso, Karen L Troy
Sep 6, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y FangK L Troy
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Matthias WalleCaitlyn J Collins

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