Bone age as a correction factor for the analysis of trabecular bone score (TBS) in children

Archives of Osteoporosis
Miguel Angel GuagnelliPatricia Clark

Abstract

Trabecular bone score (TBS) is a tool to improve evaluation of DXA scans, barely used in children. We proposed to evaluate TBS with bone age (BA) compared to chronological age (CA). In girls, TBS value using BA is constant until age 8, and in boys until age 10, and then starts to increase steadily. This data may help widen TBS use in pediatric populations. Trabecular bone score (TBS) is a software-based tool for the analysis of DXA images to assess bone microarchitecture in the lumbar region. It is used widely in adults to improve evaluation of fracture risk, yet it has been rarely studied in children and no normal curves have been developed for pediatrics. The purpose of this study was to evaluate bone (skeletal) age compared to chronological age to determine which is better in the pediatric population since both bone age (BA) and trabecular density are equally susceptible to change in response to similar factors. Total body, lumbar region, and non-dominant hand scans were obtained with an iDXA device in all participants. DXA scans of lumbar region for TBS analysis and AP images of non-dominant hand-for-BA were obtained for 565 children (269 female) aged 4to 19. Simple correlation was calculated and r2 values for TBS and chron...Continue Reading

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Citations

May 13, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mirko RehbergIbrahim Duran
Nov 16, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Yael Levy-ShragaBatia Weiss

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