Bone and bone marrow: the same organ.

Archives of Biochemistry and Biophysics
Andrea Del FattoreNadia Rucci

Abstract

Interplays between bone and bone marrow are not limited to merely anatomic and histological connections, but include a tight functional correlation. Bone marrow resides within the medullary cavity of the bones and the process of hematopoiesis is regulated, at least in part, by bone cells. Moreover, osteoclasts and osteoblasts derive from precursors of hematopoietic and mesenchymal origin, respectively, both residing within the bone marrow. Alterations in one of these components typically cause impairment in the other, so diseases of the bone marrow compartment often affect the bone and vice versa. All these findings could make us to speculate that bone and bone marrow are not two separate districts, but can be considered as the two elements of the same unique functional unit, the bone-bone marrow organ. Here we will describe histological and functional interplays between bone and bone marrow, and will illustrate some diseases in which this tight correlation is evident.

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Sep 29, 2011·Current Osteoporosis Reports·Anna Teti
Sep 7, 2011·Journal of Proteome Research·Rodrigo D A M AlvesJohannes P T M van Leeuwen
Jan 1, 2012·BoneKEy Reports·Anna Teti
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Jul 8, 2014·Archives of Biochemistry and Biophysics·Claudine Blin-WakkachAbdelilah Wakkach
Apr 16, 2015·International Journal of Endocrinology·Amélie E CoudertAndrea Del Fattore
Jun 30, 2011·Toxicology and Industrial Health·Yushui MaZongping Liu
Jul 26, 2018·Journal of Cellular and Molecular Medicine·Wen-Yan JiangHai-Yan Huang
Mar 6, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cheng-Tien WuShing-Hwa Liu
Jun 13, 2018·International Journal of Molecular Sciences·Giulia BattafaranoAndrea Del Fattore
Jan 23, 2021·Biomolecules·Mariarita SpampinatoGiuseppe A Palumbo
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Michela RossiAndrea Del Fattore
Nov 28, 2021·International Journal of Molecular Sciences·Viviana De MartinoAndrea Del Fattore

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