Bone and paraproteinemias

Current Opinion in Supportive and Palliative Care
Maurizio ZangariGuido Tricot

Abstract

Bone has always been considered a target organ for neoplastic disorder. This review analyzed the close interaction between bone microenvironment and paraproteinemias. Paraproteinemias are a group of disorders characterized by the presence of a monoclonal protein measured in the blood or urine. Paraproteinemias include nonmalignant B cell disorders such as monoclonal gammopathy of undetermined significance and malignant diseases as multiple myeloma. All these conditions are characterized by increased risk of osteoporosis/osteopenia, and in the setting of multiple myeloma can manifest with osteolytic pattern. This review focuses on the biological aspects of paraproteinemia and bone disease, and indicates possible new therapeutic interventions.

References

Nov 14, 1974·The New England Journal of Medicine·G R MundyS E Salmon
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R BerensonR D Knight
Jun 25, 1999·Journal of Leukocyte Biology·B R WongY Choi
Jan 6, 2001·Acta Oncologica·M A DimopoulosR Alexanian
May 24, 2001·Seminars in Musculoskeletal Radiology·F E LecouvetB E Maldague
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·R N PearseY Choi
Jun 5, 2003·The Journal of Clinical Investigation·I R GarrettG R Mundy
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Feb 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonRobert A Kyle
Mar 9, 2004·Blood Cells, Molecules & Diseases·G David Roodman
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonS Vincent Rajkumar
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
Sep 22, 2005·British Journal of Haematology·Maurizio ZangariGuido Tricot
Nov 30, 2005·Immunological Reviews·Lori A Ehrlich, G David Roodman
Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Aug 2, 2006·The Journal of Experimental Medicine·Anjli KukrejaMadhav V Dhodapkar
Feb 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ronald WalkerEdgardo J Angtuaco
May 23, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A KyleUNKNOWN American Society of Clinical Oncology
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Apr 26, 2008·Blood·Xin LiShmuel Yaccoby
Feb 24, 2009·Blood·Brendan M WeissW Michael Kuehl
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sonia ValletNoopur Raje

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.