Bone and the hematopoietic and immune systems: a report of the proceedings of a scientific workshop

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
W J Sharrock

Abstract

Recent observations underscore the linkage between endochondral bone formation and the establishment of hematopoietic marrow and suggest that interactions among bone, marrow, and the immune system persist in the mature skeleton. A workshop was held at the National Institutes of Health, Bethesda, Maryland, to discuss recent work on these interactions and to identify new areas of research. Marrow stromal cells include the precursors of the osteochondrogenic lineage, exert important influences on osteoclastogenesis and lymphopoiesis, and mediate the effects of some systemic factors on bone turnover. Recent evidence indicates that hematopoietic cells can influence the differentiation of osteogenic cells and suggests that mature lymphocytes can influence osteoclastic and osteoblastic functions. However, interpretation of experiments may be confounded by the potential for stage-specific responses within a cell lineage, the likelihood that divergent pathways compete for limited pools of precursor cells, and the possibility that important cells or factors are still unidentified. Further, in vitro models may be limited by species and anatomical site specificities, the absence of intermediary or accessory cells, and the absence of normal...Continue Reading

References

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Citations

May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andrea Plant, Jonathan H Tobias
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SakataT Nakamura
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D VisnjicD W Rowe
May 12, 2006·Periodontology 2000·Stan GronthosSongtao Shi
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lois E WehrenJay Magaziner
Mar 21, 2001·Circulation·E R MohlerF S Kaplan
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·M J PerryJ H Tobias
Nov 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·A MarusicJ A Lorenzo
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T S GrewalT M Skerry
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vedran KatavićAna Marusić
Mar 5, 2003·Clinical Orthopaedics and Related Research·Elizabeth A OlmstedEileen M Shore
Jul 27, 2010·Archives of Biochemistry and Biophysics·Andrea Del FattoreNadia Rucci
Feb 19, 2000·Biochemical and Biophysical Research Communications·H A MakhlufJ Glowacki

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