Bone augmentation using a highly porous PLGA/β-TCP scaffold containing fibroblast growth factor-2

Journal of Periodontal Research
T YoshidaM Kawanami

Abstract

Beta-tricalcium phosphate (β-TCP), a bio-absorbable ceramic, facilitates bone conductivity. We constructed a highly porous three-dimensional scaffold, using β-TCP, for bone tissue engineering and coated it with co-poly lactic acid/glycolic acid (PLGA) to improve the mechanical strength and biological performance. The aim of this study was to examine the effect of implantation of the PLGA/β-TCP scaffold loaded with fibroblast growth factor-2 (FGF-2) on bone augmentation. The β-TCP scaffold was fabricated by the replica method using polyurethane foam, then coated with PLGA. The PLGA/β-TCP scaffold was characterized by scanning electron miscroscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction, compressive testing, cell culture and a subcutaneous implant test. Subsequently, a bone-forming test was performed using 52 rats. The β-TCP scaffold, PLGA-coated scaffold, and β-TCP and PLGA-coated scaffolds loaded with FGF-2, were implanted into rat cranial bone. Histological observations were made at 10 and 35 d postsurgery. SEM and TEM observations showed a thin PLGA layer on the β-TCP particles after coating. High porosity (> 90%) of the scaffold was exhibited after PLGA coating, and the compressive strength of the PL...Continue Reading

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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Wei LiuDaping Wang
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Arash KhojastehLobat Tayebi
Nov 25, 2017·Advanced Healthcare Materials·Hwan D KimNathaniel S Hwang
Sep 30, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yu-Xin SunGang Li
Nov 25, 2018·Journal of Biomaterials Science. Polymer Edition·Ayako WashioYasuhiko Tabata
Aug 31, 2019·International Journal of Molecular Sciences·Margherita TumedeiMassimo Del Fabbro
Dec 21, 2017·Inflammation and Regeneration·Pornkawee CharoenlarpSachiko Iseki
Jun 15, 2021·Dental Materials Journal·Marion LabussiereXavier Struillou

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