PMID: 8601154Jan 1, 1995Paper

Bone augmentation with hydroxyapatite: histological findings in 55 cases

Implant Dentistry
W Remagen, L Prezmecky

Abstract

Bone augmentation was performed for 55 implant patients (21 male, 34 female) with hydroxyapatite granules. In 38 patients the hydroxyapatite was covered with lyophilized dura mater to avoid its loss during the healing phase. Sixty-seven punch biopsies were obtained between 14 days and 7 years. The undecalcified specimens were embedded in poly(methyl methacrylate), sectioned and stained to demonstrate bone formation. Increasing metaplastic formation of woven bone trabeculae was observed beginning with the earliest specimens. The hydroxyapatite was in intimate contact with the bone and later was partially included within its matrix. In some areas, the woven bone was resorbed by osteoclasts together with the hydroxyapatite, and mature lamellar bone was deposited by dense layers of osteoblasts. After 20 months, sufficient new bone formation occurred to permit implant insertion. In a whole mandible specimen obtained 5.6 years after implant placement, there was almost complete ossification of the hydroxyapatite. The inclusion of the titanium implants within the newly formed bone was evident, and the hydroxyapatite granules applied during second-stage surgery were firmly embedded within the newly formed trabecular bone. The bone augme...Continue Reading

Citations

Aug 18, 2009·Clinical Implant Dentistry and Related Research·Peter De CosterHugo De Bruyn
Jul 17, 2001·Journal of Periodontology·M E FritzJ Lemons
Sep 7, 1999·Journal of Periodontology·M PelegS Taicher
Oct 7, 2000·Journal of Periodontology·M E FritzJ Lemons
May 19, 2001·Clinical Implant Dentistry and Related Research·E L LiljenstenP Thomsen

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