Bone biomarker for the clinical assessment of osteoporosis: recent developments and future perspectives

Biomarker Research
Tsung-Rong Kuo, Chih-Hwa Chen

Abstract

Bone biomarkers included formation, resorption and regulator are released during the bone remodeling processes. These bone biomarkers have attracted much attention in the clinical assessment of osteoporosis treatment in the past decade. Combination with the measurement of bone mineral density, the clinical applications of bone biomarkers have provided comprehensive information for diagnosis of osteoporosis. However, the analytical approaches of the bone biomarkers are still the challenge for further clinical trials. In this mini-review, we have introduced the functions of bone biomarkers and then recently developed techniques for bone biomarker measurements have been systematically integrated to discuss the possibility for osteoporosis assessment in the early stage.

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Methods Mentioned

BETA
X-ray
imaging techniques
blood draw
glycosylation
enzyme-linked immunosorbent assay
ELISA
transgenic

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