Bone biomarkers help grading severity of coronary calcifications in non dialysis chronic kidney disease patients.

PloS One
Marion MorenaJean-Paul Cristol

Abstract

Osteoprotegerin (OPG) and fibroblast growth factor-23 (FGF23) are recognized as strong risk factors of vascular calcifications in non dialysis chronic kidney disease (ND-CKD) patients. The aim of this study was to investigate the relationships between FGF23, OPG, and coronary artery calcifications (CAC) in this population and to attempt identification of the most powerful biomarker of CAC: FGF23? OPG? 195 ND-CKD patients (112 males/83 females, 70.8 [27.4-94.6] years) were enrolled in this cross-sectional study. All underwent chest multidetector computed tomography for CAC scoring. Vascular risk markers including FGF23 and OPG were measured. Logistic regression analyses were used to study the potential relationships between CAC and these markers. The fully adjusted-univariate analysis clearly showed high OPG (≥10.71 pmol/L) as the only variable significantly associated with moderate CAC ([100-400[) (OR = 2.73 [1.03;7.26]; p = 0.04). Such association failed to persist for CAC scoring higher than 400. Indeed, severe CAC was only associated with high phosphate fractional excretion (FEPO(4)) (≥38.71%) (OR = 5.47 [1.76;17.0]; p = 0.003) and high FGF23 (≥173.30 RU/mL) (OR = 5.40 [1.91;15.3]; p = 0.002). In addition, the risk to presen...Continue Reading

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Citations

Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sophie LiabeufZiad A Massy
Apr 24, 2014·Journal of Nephrology·Alejandra Montañez-BarragánAlberto Ortiz
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Jan 23, 2013·Medicina clínica·Javier Donate-CorreaJuan F Navarro-González
Apr 30, 2015·Journal of Nephrology·Anne-Sophie BargnouxPierre Fesler
Mar 28, 2016·Calcified Tissue International·Mahmut Ilker YilmazMehmet Kanbay
Apr 10, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion MorenaJean-Paul Cristol
Jul 6, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Marcin KrzanowskiWładysław Sułowicz

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA

Software Mentioned

SAS
Smartscore

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