Bone, brain & beyond

Reviews in Endocrine & Metabolic Disorders
Alexandre ChamouniFranck Oury

Abstract

In the past 15 years, the field of physiology has been radically challenged by landmark studies using novel tools of genetic engineering. Particular to our interest, the reciprocal interactions between the skeleton and the nervous system were shown to be major ones. The demonstration that brain, via multiple pathways, is a powerful regulator of bone growth, has shed light on an important central regulation of skeletal homeostasis. More recently, it was shown that bone might return the favor to the brain through the secretion of a bone-derived hormone, osteocalcin. The skeleton influences development and cognitive functions of the central nervous system at different stages throughout life suggesting an intimate dialogue between bone and brain.

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Citations

Nov 3, 2016·Age and Ageing·Steven BradburnChris Murgatroyd
Jun 16, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chenshuang LiChia Soo
Feb 1, 2018·Médecine sciences : M/S·Julien Oury, Franck Oury
Jun 9, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Steph M BergerSophia C Dent
Nov 26, 2019·Reviews in Endocrine & Metabolic Disorders·Ebtesam Abdullah Al-Suhaimi, Meneerah Abdulrahman Al-Jafary
Jul 17, 2020·International Journal of Molecular Sciences·Ellen OttoJohannes Keller
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Hongzhen ChenChao Liang

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