PMID: 8588965Jan 1, 1995Paper

Bone cement implantation syndrome. A prospective randomised trial for use of antihistamine blockade

Archives of Orthopaedic and Trauma Surgery
W R LamadéP J Meeder

Abstract

Bone cement implantation syndrome (BCIS) is characterised by hypotension, hypoxaemia, cardiac arrhythmias, cardiac arrest or any combination of these, leading to death in 0.6-1% of patients. One of the mechanisms suggested to explain these complications is diffuse microembolisation of the lungs as a consequence of extrusion of the bone marrow content by the pressurised bone cement. By reducing intramedullary pressure and changing the operative technique, BCIS can be diminished, but deaths still occur. An anaphylactoid mechanism as a major factor in BCIS is receiving renewed attention since increased plasma histamine levels were recently demonstrated after the implantation of bone cement and a prosthesis. Therefore, we conducted a prospective, randomised study to demonstrate the potential benefit of histamine-receptor-blocking agents in patients undergoing cemented hip arthroplasty. Thirty patients were divided into two groups: group 1, the control group, received no histamine-receptor-blocking agents; group 2, the antihistamine group, received H1 and H2-receptor-blocking agents in standard dosages preoperatively. Both groups were comparable concerning age, sex and physical status (ASA criteria). There was no hospital mortality ...Continue Reading

References

Feb 1, 1991·Acta Orthopaedica Scandinavica·J S JensenK Skydsgaard
Jan 1, 1986·Annales Françaises D'anesthèsie Et De Rèanimation·G TordjmannP Vivin
Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·C UlrichH Heinrich
Jan 1, 1985·Archives of Orthopaedic and Trauma Surgery·N SvartlingL Tarkkanen
Dec 1, 1973·Anesthesiology·W Y ParkT E Macnamara
Jan 1, 1974·Upsala Journal of Medical Sciences·G HallinS Olerud
Feb 5, 1972·British Medical Journal·D J PeeblesB R Simpson
Aug 8, 1970·British Medical Journal·J N PowellP Hill
Jan 1, 1980·Archives of Orthopaedic and Trauma Surgery·H Rinecker
Feb 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J CHARNLEY

❮ Previous
Next ❯

Citations

Nov 20, 2003·Ophthalmic Plastic and Reconstructive Surgery·Malena M AmatoDavid E E Holck
May 5, 2006·Clinical Orthopaedics and Related Research·Richard J HarrisonSean P Scully
Jul 30, 2014·The American Journal of Forensic Medicine and Pathology·Sébastien de FroidmontCristian Palmiere
Nov 12, 2015·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Wangang GuoChen Wang
Sep 1, 1998·Journal of Anesthesia·Kiyoshi Terasako
Feb 15, 2011·American Journal of Therapeutics·Ankur KalraSergio L Zanotti-Cavazzoni
Nov 20, 2013·Journal of Biomedical Materials Research. Part a·Hajime MinamikawaTakahiro Ogawa
Apr 5, 2020·International Journal of Molecular Sciences·Yoshihiko SugitaTakahiro Ogawa
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R S Pumphrey
Apr 12, 2016·Orthopedics·Amish A Naik, Steven A Lietman
Oct 4, 2011·Neurosurgical Focus·Wesley HsuZiya L Gokaslan
Sep 13, 2012·Implant Dentistry·Jae Hoon Lee, Takahiro Ogawa
Sep 25, 2017·BMJ Case Reports·Muhammad Nouman BaigColin G Murphy
Apr 18, 2013·Orthopedics·David L RothbergStephen K Aoki
Jan 27, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Karoline WeingärtnerThomas Lustenberger
Apr 23, 2009·Journal of the American Chemical Society·Chong-yang Liu, Allen J Bard
Dec 9, 2008·British Journal of Anaesthesia·A J DonaldsonN W Kenny

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.