PMID: 3766725Oct 1, 1986Paper

Bone changes due to pregnancy and lactation: influence of vitamin D status

The American Journal of Physiology
P J MarieL Miravet

Abstract

The effects of pregnancy and lactation on endosteal bone formation and resorption were evaluated in vitamin D-depleted (-D) and vitamin D-repleted (+D) rats. Pregnancy induced a marked stimulation of osteoclastic bone resorption and of static and dynamic parameters of bone formation and mineralization. Bone resorption increased independently of vitamin D status and did not correlate with plasma 1,25-dihydroxyvitamin D3 [1,25(OH)2D] levels, but it was associated with increased plasma immunoreactive parathyroid hormone (iPTH) concentrations. Stimulation of the endosteal bone formation rate was mainly impaired in D-depleted rats, resulting in trabecular bone loss, which, in -D mother rats, was associated with decreased bone ash and total bone calcium. Lactation further stimulated bone resorption and reduced the trabecular bone volume; ash weight and bone calcium content were also decreased independently of the vitamin D status and changes in plasma iPTH levels. In presence of vitamin D, the bone formation rate increased fourfold during lactation but was unchanged in -D lactating rats. During lactation, vitamin D-depleted rats lost twofold more calcified bone than +D rats because of impaired mineralization. Thus, the present study ...Continue Reading

References

Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R IsaacR Ardaillou
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J G Haddad, K J Chyu
Jan 1, 1971·Calcified Tissue Research·M BlanusaK Kostial
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Jan 1, 1983·Reproduction, Nutrition, Development·P J Marie
Sep 1, 1982·The Journal of Endocrinology·C J RobinsonI MacIntyre
Dec 1, 1980·Endocrinology·B P Halloran, H F DeLuca
Apr 1, 1957·The American Journal of Physiology·R H WASSERMANF W LENGEMANN

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Citations

May 9, 2007·The Journal of Veterinary Medical Science·Norio YamagishiYoshihisa Naito
Sep 19, 2009·Calcified Tissue International·Casey L KoreckiGlen L Niebur

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