PMID: 8586778Jun 1, 1995Paper

Bone composition and histological analysis of young and aged rats fed diets of varied calcium bioavailability

Journal of the American College of Nutrition
C A PetersonJ W Erdman

Abstract

The effects of varied calcium bioavailability on bone development (young animal) and bone maintenance (aged animal) were evaluated by the application of bone composition and histologic/histomorphometric techniques. Groups of male young (3-4 weeks old) and aged (24-month-old) rats were fed nutritionally-complete but calcium-restricted (0.15%) diets in which calcium was derived from spinach or nonfat dry milk (NFDM). A 0.5% calcium casein-based diet group was included as a comparison at the National Research Council's requirement level. All animals were pair-fed to the spinach-fed group. At the end of 60 days, lumbar vertebrae, tibia and femurs were harvested for bone histomorphometric and bone composition analyses. Histological analysis of the fifth lumbar vertebral body of the young spinach-fed group showed retarded development and mineralization of trabecular bone. Histomorphometry revealed that the spinach-fed group seemed to respond to the lower bioavailable calcium source by reducing the mineralization of bone matrix and stimulating bone resorption with a resultant decrease in bone volume (0.027, 0.059, 0.068 mm3 in spinach, NFDM and 0.5% calcium casein-based diet groups, respectively). The aged animals, however, appeared t...Continue Reading

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Citations

Apr 18, 2008·The Angle Orthodontist·Koji WatanabeKenshi Maki
Jan 23, 1999·The Journal of Nutrition·F Bronner, D Pansu
Dec 24, 2005·Nutrition Reviews·Jo M Welch, Connie M Weaver

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