Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
María José Pérez-SáezJ Pascual

Abstract

Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture's estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. BMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients. Recently, trabecular bone score (TBS) and microindentation that can measure microarchitectural and mechanical properties of bone have demonstrated better correlation with fractures than DXA in different populations. We aimed to characterize bone health (BMD, TBS, and strength) and calcium/phosphate metabolism in a cohort of 53 ESRD patients undergoing kidney transplantation (KT) and 94 controls with normal renal function. Laboratory workout, lumbar spine/hip BMD measurements (using DXA), lumbar spine TBS, and bone strength were carried out. The latter was assessed with an impact microindentation device, standardized as percentage of a reference value, and expressed as bone material strength index (BMSi) units. Multivariable line...Continue Reading

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Jul 29, 2016·Transplantation·María José Pérez-SáezJulio Pascual

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Citations

Jul 10, 2018·Clinical Transplantation·Ashish K SharmaRosemary Masterson
Apr 2, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marco BonaniRudolf P Wüthrich
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Feb 23, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R WakolbingerP Pietschmann
Jun 30, 2018·Journal of Bone and Mineral Metabolism·Hye Eun YoonKwi Young Kang
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May 23, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C RampersadN Tangri
Apr 16, 2019·Clinical Reviews in Bone and Mineral Metabolism·Andrew ChangSimon Y Tang

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