Bone dielectric property variation as a function of mineralization at microwave frequencies.

International Journal of Biomedical Imaging
Paul M MeaneyKeith D Paulsen

Abstract

A critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we investigate the microwave dielectric properties of ex vivo trabecular bone with respect to bulk density measures. We exploit a variation in our tomographic imaging system in conjunction with a new soft prior regularization scheme that allows us to accurately recover the dielectric properties of small, regularly shaped and previously spatially defined volumes. We studied six excised porcine bone samples from which we extracted cylindrically shaped trabecular specimens from the femoral heads and carefully demarrowed each preparation. The samples were subsequently treated in an acid bath to incrementally remove volumes of hydroxyapatite, and we tested them with both the microwave measurement system and a micro-CT scanner. The measurements were performed at five density levels for each sample. The results show a strong correlation between both the permittivity and conductivity and bone volume fraction and suggest that microwave imaging may be a good candidate for evaluating overall bo...Continue Reading

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Citations

Mar 22, 2014·Medical & Biological Engineering & Computing·Ramiro M IrastorzaFernando Vericat
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Omer KaygiliA Birkan Selçuk
Jan 29, 2013·Medical Engineering & Physics·R M IrastorzaF Vericat
May 23, 2015·IEEE Transactions on Bio-medical Engineering·Rohit ChandraRam M Narayanan
Jun 26, 2013·IEEE Transactions on Medical Imaging·Matthew McGarryKeith D Paulsen
Jul 26, 2012·IEEE Transactions on Bio-medical Engineering·Paul M MeaneyKeith D Paulsen
May 31, 2017·Medical Physics·Paul M MeaneyKeith D Paulsen
Dec 22, 2019·Medical & Biological Engineering & Computing·J E FajardoR M Irastorza
Aug 31, 2018·Medical & Biological Engineering & Computing·Bilal AminMartin O'Halloran
Feb 11, 2020·Medical Engineering & Physics·Bilal AminMuhammad Adnan Elahi
May 27, 2021·Biomedical Physics & Engineering Express·Carlos I CardonaJuliana Ortiz-Jimenez
Jan 7, 2019·Biomedical Physics & Engineering Express·Bilal AminMartin O'Halloran
Jul 8, 2020··Bilal AminMartin O'Halloran

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Methods Mentioned

BETA
X-ray

Software Mentioned

GE MicroView

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