Bone disease drug discovery: examining the interactions between osteoblast and osteoclast

Expert Opinion on Therapeutic Targets
Sengen Sun

Abstract

Existing drugs, including bisphosphonates and calcitonin, cannot meet the strong demand for a possible cure of bone diseases - the prevailing cause of human disabilities. To understand on-going drug discovery activities, new trends and different opinions in the treatment of bone diseases. Search, summarize and analyze the recent literature up to August 2007, related to osteoporosis and joint diseases. The drug discovery based on the molecular mechanism of bone remodeling has made some progress, but there are challenges, difficulties and different opinions. Bone resorption by osteoclasts is directly regulated by osteoblasts via the receptor activator of NF-kappaB/receptor activator of NF-kappaB ligand/osteoprotegerin signaling pathway, whereas the regulation of bone formation is poorly understood. Several aspects, including the present state and future trends, are commented as the expert opinions in this paper.

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Citations

Mar 23, 2010·Expert Opinion on Therapeutic Patents·Keiichi Masuya, Naoki Teno
Feb 24, 2009·Bioorganic & Medicinal Chemistry Letters·Andrew D MorleyTina J Wilkinson
Dec 22, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gethin Rh OwenHannu Larjava
Mar 12, 2010·Journal of Medicinal Chemistry·John G AllenPhilip Babij

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