Bone Disease in Mastocytosis

Immunology and Allergy Clinics of North America
Giovanni OrsoliniRoberta Zanotti

Abstract

Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures. The main factor of bone loss is the osteoclast with a relative or absolute predominance of bone resorption. The RANK-RANKL pathway seems of key importance, but histamine and other cytokines also play a significant role in the process. The predominance of resorption made bisphosphonates, as anti-resorptive drugs, the most rational treatment of bone involvement in systemic mastocytosis.

Citations

Jun 21, 2019·International Journal of Molecular Sciences·Peter ValentMassimo Triggiani
Nov 27, 2019·International Journal of Molecular Sciences·Giovanni AdamiDavide Gatti
Jan 25, 2020·International Journal of Molecular Sciences·Maria Maddalena SirufoMassimo De Martinis
Aug 26, 2020·Calcified Tissue International·Fabio Massimo UlivieriBruno Mario Cesana
Nov 27, 2020·La Radiologia medica·Antonio LeoneCesare Colosimo
May 1, 2021·Journal of Clinical Medicine·Roberta ZanottiPatrizia Bonadonna
May 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Leander P De PuysseleyrVito Sabato
Jul 6, 2021·Calcified Tissue International·Martin GehlenHeide Siggelkow
Jan 13, 2022·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Aadit ShahFazel Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Maurizio RossiniDavide Gatti
Immunology and Allergy Clinics of North America
Maurizio RossiniDavide Gatti
Ugeskrift for laeger
Peter VestergaardKim Brixen
AMB : revista da Associação Médica Brasileira
J de Souza AndradeR P Dias
The American Journal of Medicine
Maurizio RossiniDavide Gatti
© 2022 Meta ULC. All rights reserved