Bone elasticity and ultrasound velocity are affected by subtle changes in the organic matrix

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S MehtaP P Antich

Abstract

The mechanical competence of bone can be studied through the measurement of the components of its material elasticity, a property which can vary both in magnitude and in dependence upon orientation (anisotropy). While it is known that the elasticity is largely determined by the mineral constituents of the bone matrix, it is nonetheless clear that it must be also dependent upon the remaining constituents of bone material. In this work, the influence of organic components on the elasticity is explored by altering specific constituents of the bone matrix to varying degrees. This study addresses two questions: first, are the resulting changes in elasticity strongly or weakly dependent upon direction, and second, are they substantially dependent upon the nature and magnitude of the induced matrix alteration? To answer these questions, we performed different chemical manipulations of the bone matrix and measured the changes in elasticity and velocity using the technique of ultrasound critical angle reflectometry. Altering the properties of the organic matrix resulted in substantial and complex changes in the elasticity of bone. The observed changes were strongly dependent upon direction, could not be explained by changes in density a...Continue Reading

References

Jan 1, 1977·Journal of Biomechanics·S Lees, C L Davidson
Jan 1, 1991·Journal of Biomechanics·M Volpi, E P Katz
Apr 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P P AntichC Y Pak
Aug 1, 1991·Calcified Tissue International·C H Turner, M Eich
May 26, 1989·JAMA : the Journal of the American Medical Association·R P HeaneyG H Brandenburger
Jan 1, 1989·Journal of Biomechanics·R B AshmanC H Turner
Jan 1, 1987·Journal of Biomechanics·R B AshmanC H Turner
Apr 1, 1985·Engineering in Medicine·I HvidJ C Djurhuus
Nov 1, 1972·Journal of Biomechanics·S Lees, F R Rollins
Jan 1, 1974·Journal of Biomechanics·M H Pope, J O Outwater
Dec 1, 1984·IEEE Transactions on Bio-medical Engineering·J L Katz, H S Yoon
Jan 1, 1984·Calcified Tissue International·J L KatzP Christel
Jan 1, 1982·Journal of Biomedical Engineering·W Bonfield, A E Tully
May 1, 1981·Journal of Biomechanical Engineering·W C Van BuskirkR N Ward
Jan 3, 1980·Nature·J L Katz
Jun 1, 1980·Acta Orthopaedica Scandinavica·T D Brown, A B Ferguson
Nov 1, 1994·Calcified Tissue International·K HasegawaD B Burr
Jan 1, 1993·Calcified Tissue International·P P Antich
Jan 1, 1993·Calcified Tissue International·G Marotti
Jan 1, 1993·Calcified Tissue International·S M Ott
Apr 1, 1993·Journal of Biomechanics·J F Mammone, S M Hudson
Feb 1, 1993·Journal of Biomedical Materials Research·B B TomazicE D Eanes
Mar 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P P AntichC Rubin
May 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J J Kaufman, T A Einhorn
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y TakanoD B Burr
Jan 1, 1997·Annals of Biomedical Engineering·S S KohlesR Vanderby
Mar 1, 1969·Journal of Biomechanics·J D Currey
Mar 1, 1969·Journal of Biomechanics·F G Evans, R Vincentelli
Oct 1, 1969·Journal of Biomechanics·J D Currey

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Citations

Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N P CamachoA L Boskey
Sep 23, 2003·Journal of Biomechanics·Ray Vanderby, Paolo P Provenzano
Feb 24, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Edmond RicherCharles Y C Pak
Sep 19, 2000·Tissue Engineering·K A AthanasiouX Wang
Apr 20, 2000·Connective Tissue Research·S S MehtaW J Landis
Aug 8, 2015·Computer Methods in Biomechanics and Biomedical Engineering·E LefèvreM Pithioux
Jul 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Pascal Laugier
Jan 2, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Szilvia MészárosCsaba Horváth
Feb 25, 2003·Journal of Biomechanical Engineering·C L Schwartz-Dabney, P C Dechow
Feb 21, 2004·American Journal of Veterinary Research·Frederick E T PauwelsRichard B Evans
Jun 19, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alan C SeifertFelix W Wehrli
Oct 22, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ya-Jun MaJiang Du
Feb 22, 2011·Journal of Pediatric Gastroenterology and Nutrition·Francesco PortaMarco Spada
Jul 26, 2000·Current Opinion in Rheumatology·C Roux, M Dougados
Sep 13, 2011·Experimental Biology and Medicine·Xiao ChenHanfang Xiao
Aug 23, 2001·Ultrasound in Medicine & Biology·S S MehtaE Richer

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