Bone Generation Profiling Around Photofunctionalized Titanium Mesh

The International Journal of Oral & Maxillofacial Implants
Makoto HirotaTakahiro Ogawa

Abstract

The aim of this study was to evaluate whether photofunctionalization of titanium mesh enhances its osteoconductive capability. The titanium mesh (0.2 mm thickness) used in this study was made of commercially pure grade-2 titanium and had hexagonal apertures (2 mm width). Photofunctionalization was performed by treating titanium mesh with UV light for 12 minutes using a photo device immediately before use. Untreated or photofunctionalized titanium mesh was placed into rat femurs, and bone generation around titanium mesh was profiled using three-dimensional (3D) microcomputed tomography (micro-CT). A set of in vitro experiments was conducted using bone marrow-derived osteoblasts. Photofunctionalized titanium mesh surfaces were characterized by the regenerated hydrophilicity and significantly reduced surface carbon. Bone generation profiling at week 3 of healing showed that the hexagonal apertures in photofunctionalized mesh were 95% filled, but they were only 57% filled in untreated mesh, particularly with the center zone remaining as a gap. Bone profiling in slices parallel to the titanium surface showed that photofunctionalized titanium mesh achieved 90% bone occupancy 0 to 400 μm from the surface, compared with only 35% for un...Continue Reading

Citations

May 12, 2016·The Journal of Oral Implantology·Dennis Flanagan
Mar 17, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Chika KoyamaKenji Mitsudo

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