Bone graft substitutes and bone morphogenetic proteins for osteoporotic fractures: what is the evidence?

Injury
Esther M M Van Lieshout, Volker Alt

Abstract

Despite improvements in implants and surgical techniques, osteoporotic fractures remain challenging to treat. Among other major risk factors, decreased expression of morphogenetic proteins has been identified for impaired fracture healing in osteoporosis. Bone grafts or bone graft substitutes are often used for stabilizing the implant and for providing a scaffold for ingrowth of new bone. Both synthetic and naturally occurring biomaterials are available. Products generally contain hydroxyapatite, tricalcium phosphate, dicalcium phosphate, calcium phosphate cement, calcium sulfate (plaster of Paris), or combinations of the above. Products have been used for the treatment of osteoporotic fractures of the proximal humerus, distal radius, vertebra, hip, and tibia plateau. Although there is generally consensus that screw augmentation increased the biomechanical properties and implant stability, the results of using these products for void filling are not unequivocal. In osteoporotic patients, Bone Morphogenetic Proteins (BMPs) have the potential impact to improve fracture healing by augmenting the impaired molecular and cellular mechanisms. However, the clinical evidence on the use of BMPs in patients with osteoporotic fractures is ...Continue Reading

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Citations

Jun 25, 2016·Injury·Lukas KonstantinidisPeter Augat
Jun 25, 2016·Injury·Christian von Rüden, Peter Augat
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Mar 3, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiurong KeLei Zhang
Sep 7, 2018·Experimental and Therapeutic Medicine·Kui HuangSongming Peng
Aug 10, 2017·Expert Review of Medical Devices·Mauro E C GracitelliArnaldo José Hernandez
Jan 29, 2020·Journal of Materials Science. Materials in Medicine·Fabian Obregon-MianoAxel Spahr
Aug 15, 2018·Drug Delivery and Translational Research·Elisabet Segredo-MoralesCarmen Évora
Jan 13, 2021·Injury·Esther M M Van Lieshout, Dennis Den Hartog
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