Bone Health and Endocrine Care of Boys with Duchenne Muscular Dystrophy: Data from the MD STARnet

Journal of Neuromuscular Diseases
David R WeberMuscular Dystrophy Tracking and Research Network (MD STAR

Abstract

Patients with Duchenne muscular dystrophy (DMD) are at high risk of endocrine and bone health complications resulting from the high glucocorticoid (GC) doses used to treat this condition. There are limited data characterizing the clinical management of these complications. To determine the frequency of bone health screening, endocrinologist evaluation, and use of endocrine and bone health pharmacotherapy in the clinical care of males with DMD. A population based cohort study using data from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) was conducted. Clinical data was abstracted from the medical records of 683 males with DMD at five surveillance sites across the US. A DXA scan had been documented in 24% of cases; the percentage of cases with DXA varied across surveillance sites from 13% to 43%, p < 0.001. History of fracture and greater disease duration were associated with greater odds of having a DXA. Only 4.7% of cases had documentation of an endocrinologist evaluation. The frequency of documented endocrine and bone health pharmacotherapy use included calcium (42.8%), vitamin D (36.6%), bisphosphonates (13.3%), growth hormone (1.9%), testosterone (1.7%), insulin (1.2%), and metformin (0.3%)...Continue Reading

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Citations

Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Leanne M Ward, David R Weber
Apr 11, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Renu SutharNaveen Sankhyan

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