Bone induction using demineralized bone in the rabbit femur: a long-term study

Plastic and Reconstructive Surgery
M J ConcannonC L Puckett

Abstract

While traditional bone grafting is the standard for replacement of segmental bony defects, alternative options (avoiding morbidity of autologous grafts) are attractive and continue to be sought. This study attempted to determine whether demineralized bone powder could be used reliably to replace a significant bony deficit at a weight-bearing site. The long-term functional characteristics of this induced bone were analyzed to determine whether it maintained its strength and shape and reacted normally to physiologic stress over an extended period of time (12 months). In 55 New Zealand White rabbits, a 1-cm length of femur was removed (approximately 20 percent of the total length of the rabbit femur). The femur was then reconstructed with a titanium mandibular plate, leaving the gap intact. In 38 of the animals, this gap was filled with demineralized bone powder in an attempt to induce bone to form across the defect. In group 1 (n = 23), the mandibular plate remained in place for the duration of the study (12 months). In group 2 (n = 15), the plate was removed 8 weeks after placement of the demineralized bone powder, and the animals were followed for an additional 12 months. In group 3 (n = 10), nothing was placed within the bony ...Continue Reading

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Citations

Jun 27, 2003·The Journal of Craniofacial Surgery·Jeffrey A FialkovJohn E Davies
Apr 25, 2007·Annals of Plastic Surgery·Keith E FollmarDetlev Erdmann
Jul 7, 2007·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Scott WingerterHam Benghuzzi
Apr 26, 2021·Doklady. Biochemistry and Biophysics·Liang ZhaoDaozhang Cai

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