Bone involvement in young adults with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Elisa CairoliF Blasi

Abstract

Patients with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure have high prevalence of reduced bone mineral density and fragility fracture. Suboptimal 25-hydroxyvitamin D levels could significantly contribute to the development of cystic fibrosis-related bone disease. The assessment of the prevalence of cystic fibrosis-related bone disease (CFBD) and its associated risk factors in young adults with cystic fibrosis (CF) awaiting lung transplantation for end-stage respiratory failure. Clinical characteristics, bone mineral density (BMD), the parameters of calcium metabolism, including vitamin D (25OHVitD) levels, and the presence of fragility fractures were evaluated in 42 CF patients (24 females, age 34.0 ± 8.4 years) consecutively referred as lung transplant candidates. Mean 25OHVitD levels (54.9 ± 26.2 nmol/L) were below the reference range and hypovitaminosis D (25OHVitD < 75 nmol/L) was found in 34 patients (81%) and daily calcium intakes (median 550 mg/day) were lower than recommended. A BMD below the expected range for age (Z-score of - 2.0 or lower) and at least one prevalent fragility fracture were found in 22 patients (52.4%) and 18 patients (45.2%), respectively. The coexistence of low BM...Continue Reading

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Citations

Jun 26, 2020·Expert Review of Endocrinology & Metabolism·Iacopo ChiodiniLuigi Gennari
May 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Jessica PepeSerge Ferrari
Sep 17, 2020·Journal of Clinical Medicine·Carla CaffarelliStefano Gonnelli
Apr 29, 2021·Journal of Endourology·Joseph MoryousefMichael Ordon
Jun 7, 2021·Lancet·Michal ShteinbergJane C Davies
Jun 11, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gabrielle DuretteGeneviève Mailhot
Jul 9, 2021·Calcified Tissue International·Outi Mäkitie, M Carola Zillikens
Aug 10, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Giorgia GrassiCristina Eller-Vainicher

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