Bone isoenzyme of serum alkaline phosphatase in acromegaly

Clinica Chimica Acta; International Journal of Clinical Chemistry
J StĕpánV Pacovský

Abstract

In 37 patients with active acromegaly and in 15 patients with inactive acromegaly, activity of bone isoenzyme of serum alkaline phosphatase correlated (P less than 0.001) with serum concentration of immunoreactive growth hormone. By using stepwise regression analysis, the predication of serum growth hormone values based on serum levels of bone isoenzyme of serum alkaline phosphatase, gamma-glutamyl transferase and calcium in these patients with acromegaly was within 1 S.D. range in 37 patients and in only 2 patients was it out of 2 S.D. range. By using discriminant analysis, based on bone and liver isoenzymes of serum alaline phosphatase and urinary hydroxyproline excretion, 87%, 60% and 97% of the classification of patients with active and inactive acromegaly and healthy adults, respectively, was correct. The multivariate approach offers a quantitative appraisal of the biochemical parameters of peripheral growth hormone action used as an indicator of growth hormone concentration in patients with acromegaly.

References

Mar 1, 1981·The Histochemical Journal·G Huether, V Neuhoff
Jul 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P D BroulikV Pacovský
Oct 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J StĕpánV Pacovský
Oct 7, 2016·Pituitary·Gherardo MazziottiAndrea Giustina
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A SiddiqiJ P Monson
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Gherardo MazziottiAndrea Giustina
Jul 1, 1980·Annals of Clinical Biochemistry·P B Brown, K O Lewis

Citations

Jul 1, 1976·The American Journal of Medicine·J F AloiaS H Cohn
May 28, 1976·Deutsche medizinische Wochenschrift·H LepszyH L Krüskemper
Mar 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J Corvilain, M Abramow
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·B L RiggsM Singh

Related Concepts

Calcium [EPC]
Growth Hormone Activity
Phosphoric Monoester Hydrolases
Calcium
Gamma-glutamyl transferase
Acromegaly
Alkaline Phosphatase
Hydroxyproline Measurement
Serum Growth Hormone Measurement
Body Excretions

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