Bone isoenzyme of serum alkaline phosphatase in acromegaly

Clinica Chimica Acta; International Journal of Clinical Chemistry
J StĕpánV Pacovský


In 37 patients with active acromegaly and in 15 patients with inactive acromegaly, activity of bone isoenzyme of serum alkaline phosphatase correlated (P less than 0.001) with serum concentration of immunoreactive growth hormone. By using stepwise regression analysis, the predication of serum growth hormone values based on serum levels of bone isoenzyme of serum alkaline phosphatase, gamma-glutamyl transferase and calcium in these patients with acromegaly was within 1 S.D. range in 37 patients and in only 2 patients was it out of 2 S.D. range. By using discriminant analysis, based on bone and liver isoenzymes of serum alaline phosphatase and urinary hydroxyproline excretion, 87%, 60% and 97% of the classification of patients with active and inactive acromegaly and healthy adults, respectively, was correct. The multivariate approach offers a quantitative appraisal of the biochemical parameters of peripheral growth hormone action used as an indicator of growth hormone concentration in patients with acromegaly.


Mar 1, 1981·The Histochemical Journal·G Huether, V Neuhoff
Jul 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P D BroulikV Pacovský
Oct 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J StĕpánV Pacovský
Oct 7, 2016·Pituitary·Gherardo MazziottiAndrea Giustina
Apr 24, 2018·Endocrine Reviews·Gherardo MazziottiAndrea Giustina
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A SiddiqiJ P Monson
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Gherardo MazziottiAndrea Giustina
Jul 1, 1980·Annals of Clinical Biochemistry·P B Brown, K O Lewis


Jul 1, 1976·The American Journal of Medicine·J F AloiaS H Cohn
May 28, 1976·Deutsche medizinische Wochenschrift·H LepszyH L Krüskemper
Mar 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J Corvilain, M Abramow
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·B L RiggsM Singh

Related Concepts

Calcium [EPC]
Growth Hormone Activity
Phosphoric Monoester Hydrolases
Gamma-glutamyl transferase
Alkaline Phosphatase
Hydroxyproline Measurement
Serum Growth Hormone Measurement
Body Excretions

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.