Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms

Environmental Health Perspectives
H HuD Smith

Abstract

The skeleton contains the majority of the body's lead burden in both children and adults. The half-life of lead in bone is in the range of years to decades, depending on bone type, metabolic state, and subject age, among other things. Measurement of skeletal lead has benefited greatly from the recent development of X-ray fluorescence (XRF) instruments that can make rapid, safe, accurate, and relatively precise measurements of lead in bone. Two types of XRF technologies exist, LXRF and KXRF; this paper focuses on KXRF, which has been the most widely validated and used. KXRF is proving to be a powerful analytical methodology for evaluating bone lead levels as a measure of time-integrated (i.e., cumulative) lead dose in epidemiologic studies of the effects of chronic lead exposure. However, insufficient attention has been given to conceptualizing the paradigms by which bone lead levels reflect lead exposure and by which the skeleton serves as an endogenous source of lead. Consideration of these paradigms, which rely on bone lead kinetics, is necessary for the proper development of a priori hypotheses involving bone lead accumulation and release, the selection of bone sites for measurement by KXRF, and the design of epidemiologic s...Continue Reading

References

Feb 1, 1978·British Journal of Industrial Medicine·A CavalleriA Baruffini
Jan 1, 1979·Archives of Internal Medicine·R P WedeenV Batuman
Aug 1, 1976·The Journal of Clinical Investigation·M B RabinowitzJ D Kopple
Mar 1, 1992·The Journal of Clinical Endocrinology and Metabolism·M J SeibelJ P Bilezikian
Jun 1, 1991·Pharmacology & Toxicology·U NilssonS Mattsson
Feb 1, 1991·Environmental Health Perspectives·M B Rabinowitz
Feb 1, 1991·Environmental Health Perspectives·D R ChettleL J Somervaille
Feb 1, 1991·Environmental Health Perspectives·E K Silbergeld
Feb 2, 1990·JAMA : the Journal of the American Medical Association·H L Needleman, C A Gatsonis
Mar 1, 1990·Archives of Environmental Health·R D Wedeen
Dec 2, 1989·Lancet·P TothillJ F Smyth
Aug 2, 1986·Lancet·A M el-SharkawiM C Scott
Oct 1, 1988·Bone and Mineral·J M VogelP D Ross
Oct 1, 1988·Environmental Research·E K SilbergeldK Mahaffey
Nov 1, 1988·Archives of Environmental Health·L E WittmersA Alich
Mar 1, 1987·The Science of the Total Environment·A SchützI Tell
Jun 1, 1987·Scandinavian Journal of Work, Environment & Health·A Cavalleri, C Minoia
Jun 1, 1987·Scandinavian Journal of Work, Environment & Health·A SchützJ O Christoffersson
Sep 1, 1986·The Journal of Physiology·T J Simons
Jan 1, 1985·Epidemiologic Reviews·S R CummingsK J O'Dowd
Mar 1, 1985·British Journal of Industrial Medicine·W I Manton
Aug 5, 1985·The Medical Journal of Australia·G N ThompsonS Fitzgerald
Dec 1, 1968·Archives of Environmental Health·H A Schroeder, I H Tipton
Oct 1, 1970·British Journal of Industrial Medicine·P S Barry, D B Mossman
Aug 1, 1984·British Journal of Industrial Medicine·W I Manton, J D Cook
Jan 1, 1984·International Archives of Occupational and Environmental Health·H Aono, S Araki
Apr 1, 1984·Journal of Applied Toxicology : JAT·A CavalleriM Poloni
Aug 1, 1981·British Journal of Industrial Medicine·P E deSilva
Sep 15, 1980·Toxicology and Applied Pharmacology·C A Keller, R A Doherty
Jan 1, 1995·Archives of Environmental Health·J Schwartz
Dec 1, 1994·Environmental Health Perspectives·E J O'Flaherty
Jun 1, 1995·American Journal of Epidemiology·E Symanski, I Hertz-Picciotto
Nov 16, 1994·JAMA : the Journal of the American Medical Association·H HuA Rotnitzky
Nov 1, 1994·American Journal of Epidemiology·M PaytonS T Weiss
Jul 27, 1994·JAMA : the Journal of the American Medical Association·J L PirkleT D Matte
Feb 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B J GertzD R Eyre

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Citations

Aug 1, 2012·Archives of Environmental & Occupational Health·Ikaraoha Chidiebere IkechukwuMbadiwe Nkeiruka Chigaekwu
Nov 1, 2013·Environmental Science and Pollution Research International·Tasneem G KaziSadaf Sadia Arain
Jun 24, 2009·Radiology·Tsyh-Jyi HsiehWei-Chen Lin
Dec 19, 2009·Environmental Health Perspectives·Manish AroraHoward Hu
Mar 20, 2014·Annual Review of Public Health·Laura S RozekGilbert S Omenn
Jun 12, 2014·Environmental Health : a Global Access Science Source·Joseph M BraunMartha Maria Tellez-Rojo
Jan 24, 2009·Environmental Health Perspectives·Adrienne S EttingerMauricio Hernández-Avila
Dec 8, 2009·International Archives of Occupational and Environmental Health·Natalia I GolubEdwin van Wijngaarden
Dec 1, 2007·American Journal of Public Health·Parisa TehranifarSongmei Wu
May 31, 2008·American Journal of Public Health·Keson TheppeangBrian S Schwartz
May 16, 2000·Environmental Health Perspectives·A C Todd
Jul 18, 2000·Occupational and Environmental Medicine·M J BrownM Hernandez-Avila
Feb 15, 2001·Environmental Health Perspectives·H Hu
Mar 27, 2001·Environmental Health Perspectives·H FrumkinV S Hertzberg
May 11, 2002·Environmental Health Perspectives·Walter F StewartAndrew C Todd
Oct 4, 2002·Environmental Health Perspectives·Bruce A DyeDebra J Brody
Apr 5, 2003·Environmental Health Perspectives·Francisco Garrido LatorreHoward Hu
Mar 8, 2002·Environmental Health Perspectives·Donald SmithHoward Hu
May 4, 2004·Environmental Health Perspectives·Robert O WrightHoward Hu
Aug 4, 2004·Environmental Health Perspectives·Charles LinHoward Hu
Dec 8, 2004·Environmental Health Perspectives·Gertrud S BerkowitzAndrew C Todd
Jan 1, 2005·Environmental Health Perspectives·Jyme H SchaferBrian S Schwartz
May 24, 2005·Archives of Disease in Childhood·B P Lanphear, C F Bearer
Dec 7, 2005·Environmental Health Perspectives·Fernando BarbosaPatrick J Parsons
Mar 2, 2006·Environmental Health Perspectives·Nitin B Jain, Howard Hu
Nov 17, 2006·Environmental Health Perspectives·Sung Kyun ParkHoward Hu
Dec 23, 2006·Environmental Health Perspectives·Steven CoonJay Gorell
Apr 14, 2007·Environmental Health Perspectives·Howard HuBrian S Schwartz
Aug 10, 2007·Environmental Health Perspectives·Florence T WangRobert O Wright
Sep 12, 2008·Journal of Occupational and Environmental Medicine·Pradeep RajanRobert O Wright
May 30, 2009·Reviews on Environmental Health·Talia SandersPaul B Tchounwou
Jun 17, 2009·Journal of Occupational and Environmental Medicine·Huiling NieHoward Hu
Aug 25, 2009·American Journal of Epidemiology·Ana Navas-AcienVirginia Weaver
Sep 16, 2009·Epidemiology·Karen Bandeen-RocheBrian S Schwartz

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