Bone loss in patients treated with pulses of methylprednisolone is not negligible: a short term prospective observational study

Annals of the Rheumatic Diseases
G HaugebergP Emery

Abstract

To examine the influence of intravenous pulsed methylprednisolone (MP) on bone mass. 38 patients (30 women) with various rheumatic disorders requiring intravenous MP pulse treatment were examined at baseline and after 6 months with dual energy x ray absorptiometry (DXA), measuring hip and lumbar spine bone mineral density (BMD). Demographic and clinical data were collected. Demographics showed: mean (SD) age 48.4 (16.3) years, body mass index 24.9 (5.1) kg/m(2), and median (range) disease duration 3.2 (0.1-40.0) years. During follow up patients received a mean cumulative MP dose of 3.0 (1.6) g given as 5.7 (2.0) pulses over a median period of 5.7 (2.3-33.7) months. 34/38 (89%) patients were also pulsed with cyclophosphamide, 20 (53%) were taking oral corticosteroids, and 8 (21%) were using either bisphosphonates or oestrogen. At the end of the study mean BMD was reduced by -2.2% at the femoral neck, -1.1% at the total hip, and -1.0% at the spine L2-4. In subgroups BMD increased in patients treated with bisphosphonates or oestrogen (femoral neck +1.6%, total hip +3.2%, spine L2-4 +4.5%), whereas BMD decreased at all sites in patients not treated with antirersorptive treatment, both for users (femoral neck -4.4%, total hip -2.4%,...Continue Reading

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Citations

May 26, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J R CurtisK G Saag
Nov 27, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C C MokK M Ma
Nov 19, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H KajiT Sugimoto
Nov 22, 2008·Indian Journal of Pediatrics·Aditi Sinha, Arvind Bagga
Nov 11, 2010·Indian Journal of Dermatology·Dorria SalemKareem Mohammed Mohsen
Apr 12, 2016·Multiple Sclerosis and Related Disorders·Olwen MurphyJeremy Chataway
Mar 2, 2006·Ocular Immunology and Inflammation·Nikos N MarkomichelakisTasos Kouris
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Dec 15, 2012·La Revue de médecine interne·K Briot, C Roux
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May 27, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aric VaidyaYasuhiro Takahashi

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