PMID: 8452815Feb 1, 1993Paper

Bone marrow abnormalities in the non-obese diabetic mouse

International Immunology
P B LangmuirI N Crispe

Abstract

Several lines of evidence point to abnormalities of the phenotype, cytokine responses, and function of cells of the myeloid lineage in non-obese diabetic (NOD) mice. In this study we have characterized the phenotype and myeloid progenitor function of NOD bone marrow. Two hematopoietic differentiation antigens, Ly-6C and AA4.1, are expressed abnormally on NOD bone marrow cells. While multilineage erythromyeloid progenitor cells (day 12 CFU-S) are normal in number in NOD mice, more differentiated myeloid progenitors are deficient in their in vitro responses to IL-3, granulocyte/macrophage colony-stimulating factor (GM-CSF), and IL-5. Since the diabetes-predisposing Idd-5 gene of NOD mice maps close to the IL-1 receptor, we tested NOD bone marrow cells for a defect in synergy between IL-1 and IL-3; no defect was found. The defects in myelopoiesis described here may predispose the NOD mouse to autoimmunity by impairing macrophage maturation.

Citations

Oct 1, 1996·Immunology Today·F Homo-Delarche, C Boitard
Jun 1, 1997·Research in Immunology·M A Atkinson
Apr 12, 2001·Clinical and Experimental Immunology·J StridT Lund
Apr 10, 2002·Immunology and Cell Biology·Simon J Prasad, Christopher C Goodnow
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D V SerrezeE H Leiter
Dec 17, 2008·The Journal of Experimental Medicine·Anil K PanigrahiEline T Luning Prak
Dec 6, 2002·Drugs·Nikolai PetrovskyDesmond A Schatz
Jan 1, 1997·Stem Cells·B G ExnerS T Ildstad
Jan 20, 2016·Journal of Diabetes Research·Dina Silke Malling DamlundHanne Frøkiær
Dec 18, 2003·Annals of the New York Academy of Sciences·D G SilvaN Petrovsky
Dec 18, 2003·Annals of the New York Academy of Sciences·Ruihua PengM J Clare-Salzler
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Feili-Hariri, P A Morel
Jul 28, 2004·Diabetes·Paula M ChiltonSuzanne T Ildstad
Jun 1, 2002·International Immunology·Simon J Prasad, Christopher C Goodnow
Oct 20, 2005·Clinical and Experimental Immunology·F AngeliniM L Manca Bitti
Apr 25, 2008·Current Protocols in Immunology·E H Leiter
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H T KreuwelL A Sherman
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle R Simpson-AbelsonRichard B Bankert
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonard D ShultzRupert Handgretinger
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatjana NikolicPieter J M Leenen
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raymond J SteptoeLeonard C Harrison
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo A SilveiraDavid V Serreze

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