Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis

Frontiers in Endocrinology
Guojing LuoXijie Yu

Abstract

The high incidences of bone metastasis in patients with breast cancer, prostate cancer and lung cancer still remains a puzzling issue. The "seeds and soil" hypothesis suggested that bone marrow (soil) may provide a favorable "niche" for tumor cells (seed). When seeking for effective ways to prevent and treat tumor bone metastasis, most researchers focus on tumor cells (seed) but not the bone marrow microenvironment (soil). In reality, only a fraction of circulating tumor cells (CTCs) could survive and colonize in bone. Thus, the bone marrow microenvironment could ultimately determine the fate of tumor cells that have migrated to bone. Bone marrow adipocytes (BMAs) are abundant in the bone marrow microenvironment. Mounting evidence suggests that BMAs may play a dominant role in bone metastasis. BMAs could directly provide energy for tumor cells, enhance the tumor cell proliferation, and resistance to chemotherapy and radiotherapy. BMAs are also known for releasing some inflammatory factors and adipocytokines to promote or inhibit bone metastasis. In this review, we made a comprehensive summary for the interaction between BMAs and bone metastasis. More importantly, we discussed the potentially promising methods for the prevention...Continue Reading

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Citations

Oct 4, 2019·Clinical & Experimental Metastasis·Maria V DeligiorgiDimitrios T Trafalis
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May 6, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Yaongamphi Vashum, Zenith Khashim
Mar 7, 2021·International Journal of Molecular Sciences·Silvia PeregoGiovanni Lombardi

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Methods Mentioned

BETA
chip

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