Bone marrow adipose cells - cellular interactions and changes with obesity.

Journal of Cell Science
Parastoo Boroumand, Amira Klip

Abstract

The bone marrow is a spatially restricted niche, housing cells of the hematopoietic and mesenchymal lineages in various hierarchical commitment states. Although highly localized, cells within this niche are also subject to regulation by environmental and/or circulatory changes through extensive vascularization. Bone marrow adipocytes, derived from mesenchymal stem cells and once known as marrow space fillers, are a heterogeneous population. These cells reside in distinct niches within the bone marrow and interact with proximal cells, such as hematopoietic precursors and lineage-committed cells. In this diverse cellular milieu, bone marrow adipocytes influence commitment decisions and cellular lineage selection by interacting with stem and progenitor cells. In addition, bone marrow adipocytes respond to environmental changes, such as obesity, by undergoing hypertrophy, hyperplasia or adoption of characteristics resembling those of peripheral brown, beige or white adipocytes. Here, we review recent findings and concepts on the influence of bone marrow adipocytes on hematopoietic and other cellular lineages within this niche. We discuss how changes in local, systemic, cellular and secreted signals impact on mesenchymal stem cell e...Continue Reading

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Citations

Jul 18, 2020·International Journal of Molecular Sciences·Eunah Shin, Ja Seung Koo
Sep 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShangHui Ren
Nov 27, 2020·Journal of Cellular Physiology·Qi ShangHui Ren
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May 22, 2021·Frontiers in Cell and Developmental Biology·Stefania CrippaMaria Ester Bernardo

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