Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis

Haematologica
Zengdi ZhangHai-Bin Ruan

Abstract

Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular and molecular mechanisms mediating the metabolic sensing and regulation remain largely obscure. Bone marrow adipose tissue remodels in various metabolic conditions and has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated the role of marrow adipose tissue-derived hematopoietic cytokine stem cell factor in unperturbed hematopoiesis by selectively ablating the Kitl gene from adipocytes and bone marrow stroma cells using Adipoq-Cre and Osx1-Cre, respectively. We found that both Adipoq-Kitl knockout (KO) and Osx1-Kitl KO mice diminished hematopoietic stem and progenitor cells and myeloid progenitors in the bone marrow and developed macrocytic anemia at the steady-state. The composition and differentiation of hematopoietic progenitor cells in the bone marrow dynamically responded to metabolic challenges including high fat diet, β3-adrenergic activation, thermoneutrality, and aging. However, such responses, particularly within the myeloid compartment, were largely impaired in Adipoq-Kitl KO mice. Our data demonstrate that marrow adipose tissue provides stem cell f...Continue Reading

Citations

Apr 24, 2020·Circulation Research·Maximilian J SchlossMatthias Nahrendorf
Jun 1, 2020·Leukemia·Julia ZinngrebePamela Fischer-Posovszky
Oct 18, 2020·Current Osteoporosis Reports·Sarah E Little-LetsingerMaya Styner
Nov 14, 2020·Current Opinion in Rheumatology·Natalia Zapata-LinaresXavier Houard
Apr 5, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Leilei ZhongLing Qin
May 22, 2021·Frontiers in Cell and Developmental Biology·Stefania CrippaMaria Ester Bernardo
Jul 7, 2021·Experimental Hematology·Berenice Meza-LeónEugenia Flores-Figueroa
Aug 22, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Josefine TratwalOlaia Naveiras
Sep 29, 2021·Obesity·Kiley B Vander WystGabriel Q Shaibi

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Methods Mentioned

BETA
Protein Assay
ELISA
flow cytometry

Software Mentioned

Excel
EchoMRI
GraphPad Prism

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