PMID: 7542579Mar 1, 1995Paper

Bone marrow and serum connective tissue polypeptides in idiopathic myelofibrosis

Clinical and Laboratory Haematology
J T ReillyA Smith

Abstract

The distribution of collagen type VI and tenascin has been determined in both normal and myelofibrotic bone marrow by immunohistological techniques. In normal sections positivity was demonstrated in the periosteum (collagen type VI and tenascin) and in the walls of small blood vessels (tenascin). In contrast, myelofibrotic bone marrow showed an increased deposition of both proteins, especially collagen type VI, although this increase was restricted to the later fibrotic stages of the disease. Serum concentrations of collagen type I (PICP), collagen type III (PIIIP) and laminin (laminin P1) related polypeptides were determined in a further 26 patients. PIIIP levels were significantly raised, in contrast to PICP and laminin P1 concentrations. All three markers, however, were significantly elevated in patients with active/transforming disease. Laminin P1 and PICP levels showed a strong correlation, indicating a relationship between basement membrane and interstitial collagen metabolism, although they do not appear to offer any advantage over PIIIP for the monitoring of disease activity.

References

Jun 1, 1992·Journal of Clinical Pathology·J T Reilly
Dec 1, 1991·British Journal of Haematology·J T Reilly, G Dolan
Dec 1, 1988·Journal of Clinical Pathology·J T Reilly, J R Nash
Apr 1, 1989·British Journal of Haematology·A PagliucaG J Mufti
Jan 1, 1988·Annual Review of Cell Biology·R E Burgeson
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Aug 1, 1985·British Journal of Haematology·J T ReillyB A McVerry
Mar 1, 1993·Journal of Clinical Pathology·Y SoiniV P Lehto
Jan 1, 1993·European Journal of Haematology·R BartlW Wilmanns

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Citations

Jan 13, 2000·The American Journal of Surgical Pathology·E D RemsteinA G Nascimento
Mar 3, 2004·The Journal of Clinical Investigation·Medhat ShehataHeinz Gisslinger
May 25, 2001·International Journal of Hematology·A Tefferi
Feb 18, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rosmarie SuetterlinR Hubert Laeng
Jan 1, 1998·Hematology·J T Reilly

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