PMID: 6968214Sep 1, 1980Paper

Bone marrow as the major site of antierythrocyte autoantibody production in NZB mice

Arthritis and Rheumatism
P L Cohen

Abstract

By use of a hemolytic plaque assay, it has been determined that most cells secreting the clinically important (anti-X) erythrocyte autoantibody of NZB mice are located in the bone marrow. There was evidence of excessive polyclonal B cell activation in NZB spleen but not in bone marrow, despite the role of marrow as the major source of erythrocyte autoantibody. These findings suggest that polyclonal activation of B cells within the marrow does not lead to erythrocyte autoantibody production. Small but significant numbers of antierythrocyte autoantibody producing cells were detected in the bone marrow but not in the spleens of normal mice, indicating that tolerance to erythrocytes may be less absolute in the bone marrow than in the spleen, or that the bone marrow serves as a repository for autoantibody secreting cells generated elsewhere.

References

Oct 1, 1976·The Journal of Clinical Investigation·J H VaughanR McMillan
Jan 1, 1970·Advances in Immunology·N I Abdou, M Richter
Jan 1, 1971·International Archives of Allergy and Applied Immunology·O J Mellbye
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
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Mar 1, 1957·The Journal of Infectious Diseases·L R DRAPER, D H SUSSDORF
Apr 26, 1963·Science·N K Jerne, A A Nordin

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