Abstract
Emerging evidence suggests that bone-marrow-derived stem and progenitor cells can be used to improve cardiac function after acute myocardial infarction. We tested this concept in the randomized, controlled, BOOST (bone marrow transfer to enhance ST-elevation infarct regeneration) clinical trial. Following successful percutaneous coronary intervention for acute ST-elevation myocardial infarction, patients received an intracoronary transfer of autologous bone marrow cells (BMCs). After 6 months, global left ventricular ejection fraction, as determined by magnetic resonance imaging, was significantly improved in the BMC-treated group compared with the control group. BMC transfer enhanced left ventricular systolic function, primarily in myocardial segments adjacent to the infarcted area, and also had a positive effect on diastolic function. BMC transfer did not increase the risk of adverse clinical events and did not promote in-stent re-stenosis or proarrhythmic effects. In principle, the effects of BMC transfer on ejection fraction were sustained at 18-month follow-up. Notably, radioactive labeling of BMCs and positron emission tomography showed that these beneficial effects are achieved with limited cardiac homing of BMCs after i...Continue Reading
References
Apr 3, 2001·Nature Medicine·A A KocherS Itescu
Apr 5, 2001·Nature·D OrlicP Anversa
Aug 29, 2001·Circulation·H KamihataT Iwasaka
Oct 9, 2002·Circulation·Bodo E StrauerPeter Wernet
Dec 11, 2002·Circulation·Birgit AssmusAndreas M Zeiher
Jul 13, 2004·Lancet·Kai C WollertHelmut Drexler
Sep 11, 2004·Circulation Research·Francisco Fernández-AvilésAna Sánchez
Feb 5, 2005·Circulation Research·Kai C Wollert, Helmut Drexler
Apr 27, 2005·Circulation·Michael HofmannHelmut Drexler
Citations
Sep 1, 2008·Journal of Cardiovascular Translational Research·Alexander R LyonNicholas S Peters
Oct 5, 2007·Annual Review of Medicine·Benjamin D Humphreys, Joseph V Bonventre
Jul 17, 2008·Biological Chemistry·Alicia Rovó, Alois Gratwohl
Jan 31, 2012·Imaging in Medicine·Yingli FuDara L Kraitchman
Oct 16, 2013·International Journal of Molecular Medicine·Shaohua Qi, Dongcheng Wu
Nov 6, 2009·Acta Biomaterialia·Peter M Crapo, Yadong Wang
Apr 9, 2008·Journal of Molecular and Cellular Cardiology·Victoria L T Ballard, Jay M Edelberg
Dec 13, 2006·Life Sciences·Makoto SumiRyozo Nagai
Aug 9, 2012·Thrombosis and Haemostasis·Wojciech WojakowskiJozef Dulak
Jun 4, 2010·Journal of Cellular and Molecular Medicine·Cristiano SpadaccioJorge A Genovese
Mar 24, 2012·Journal of Surgical Oncology·Philip S MullenixEdmund P Alexander
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Victoria L T Ballard, Jay M Edelberg
Apr 28, 2007·Cytotherapy·I McNiece
Nov 26, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Sunil RangappaJames Forrester
Jul 9, 2008·Coronary Artery Disease·Sheng KangRun-Lin Gao
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sheik WiselPeriannan Kuppusamy
Sep 6, 2012·Nanotechnology·Rajeswari RavichandranSeeram Ramakrishna
Jul 31, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Mahmood KhanPeriannan Kuppusamy