Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart.

Journal of Cellular and Molecular Medicine
Lucio BarileMaria Cristina Magli

Abstract

Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit(+) CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit(+) CSCs.

References

Feb 11, 1982·Nature·M C MagliN Odartchenko
Jun 8, 2001·The Journal of Clinical Investigation·K A JacksonM A Goodell
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·G CondorelliG Cossu
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Apr 5, 2002·Nature·Qi-Long YingAustin G Smith
Oct 22, 2002·FEBS Letters·Andrée M HierlihyLynn A Megeney
Feb 27, 2003·Pediatric Transplantation·Donald OrlicPiero Anversa
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Jan 2, 2004·The Journal of Biological Chemistry·Katsuhisa MatsuuraIssei Komuro
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Antonio MusaròNadia Rosenthal
Mar 23, 2004·Nature·Kenneth R Chien
Oct 9, 2004·Circulation Research·Elisa MessinaAlessandro Giacomello
Feb 1, 2005·Developmental Biology·Daniel Eberhard, Harald Jockusch
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Jul 11, 2006·The Journal of Clinical Investigation·Kenneth R Chien
Aug 24, 2006·Journal of Molecular and Cellular Cardiology·Yigang WangMuhammad Ashraf
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Aug 1, 2007·Molecular and Cellular Biology·Doria FilipponiSusanna Dolci

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Citations

Apr 5, 2011·Tissue Engineering. Part C, Methods·Agmal ScherzedNorbert Kleinsasser
Oct 26, 2011·Cells, Tissues, Organs·John M WainwrightStephen F Badylak
Dec 12, 2012·Journal of Biomedicine & Biotechnology·Lucio BarileGiuseppe Vassalli
Nov 22, 2011·Journal of Cellular and Molecular Medicine·Lucio Barile, Vincenzo Lionetti
May 23, 2012·Journal of Cellular and Molecular Medicine·Zhuzhi WenJingfeng Wang
Oct 21, 2015·Frontiers in Cell and Developmental Biology·Amanda Finan, Sylvain Richard
Jan 1, 2015·Heart Failure Reviews·Wang ZhaoShui-Ping Zhao
Jan 18, 2014·Circulation Research·Susmita Sahoo, Douglas W Losordo
Jun 28, 2016·Scientific Reports·Na LiuZongjin Li
Jan 10, 2020·Cardiovascular Engineering and Technology·Reza AbbasgholizadehRavi K Birla
May 16, 2013·Journal of Cardiovascular Pharmacology·Jianqin Ye, Yerem Yeghiazarians
Jul 6, 2019·Frontiers in Endocrinology·Fabiola MarinoDaniele Torella

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Methods Mentioned

BETA
biopsy
transgenic
PCR

Software Mentioned

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