Bone marrow-derived cells contribute to cell turnover in aging murine hearts

International Journal of Molecular Medicine
Sebastian SzardienHelge Möllmann

Abstract

The paradigm that cardiac myocytes are non-proliferating, terminally differentiated cells was recently challenged by studies reporting the ability of bone marrow-derived cells (BMCs) to differentiate into cardiomyocytes after myocardial damage. However, little knowledge exists about the role of BMCs in the heart during physiological aging. Twelve-week-old mice (n=36) were sublethally irradiated and bone marrow from littermates transgenic for enhanced green fluorescent protein (eGFP) was transplanted. After 4 weeks, 18 mice were sacrificed at the age of 4 months and served as controls (group A); the remaining mice were sacrificed at the age of 18 months (group B). Group A did not exhibit a significant number of eGFP+ cells, whereas 9.4±2.8 eGFP+ cells/mm2 was documented in group B. In total, only five eGFP+ cardiomyocytes were detected in 20 examined hearts, excluding a functional role of BM differentiation in cardiomyocytes. Similarly, a relevant differentiation of BMCs in endothelial or smooth muscle cells was excluded. In contrast, numerous BM-derived fibroblasts and myofibroblasts were observed in group B, but none were detected in group  A. The present study demonstrates that BMCs transdifferentiate into fibroblasts and myo...Continue Reading

References

May 5, 1997·FEBS Letters·M OkabeY Nishimune
Jun 8, 2001·Mechanisms of Ageing and Development·C R Gazoti DebessaR Rodrigues de Souza
Jun 8, 2001·The Journal of Clinical Investigation·K A JacksonM A Goodell
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Mar 23, 2002·Experimental Gerontology·Federica I WolfAchille Cittadini
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·K ShivakumarEdward G Lakatta
Feb 27, 2003·Pediatric Transplantation·Donald OrlicPiero Anversa
Mar 17, 2005·Cardiovascular Research·Georg Ertl, Stefan Frantz
Jul 21, 2006·Cardiovascular Research·Helge MöllmannAlbrecht Elsässer
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Aug 10, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Florian Tögel, Christof Westenfelder
Apr 5, 2008·Journal of the American College of Cardiology·Marcin BujakNikolaos G Frangogiannis
Jun 5, 2008·European Heart Journal·Enca Martin-RendonSuzanne M Watt
Sep 6, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Piper M TreutingWarren C Ladiges
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Kathrin I OdörferReinhold G Erben
Jun 26, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Marcus DanielDaniel G Sedding

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Citations

Sep 19, 2012·Journal of Cardiovascular Translational Research·Carolina Vasquez, Gregory E Morley
Jan 17, 2016·Journal of Molecular and Cellular Cardiology·Evangelos P DaskalopoulosSandrine Horman
Feb 3, 2016·Chinese Medical Journal·Rong-Jie LinShuang-Lun Xie
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis
Jun 21, 2019·Circulation Research·Nikolaos G Frangogiannis
Oct 2, 2020·International Journal of Molecular Sciences·Denisa BaciAntonino Bruno
Mar 9, 2017·Canadian Journal of Physiology and Pharmacology·Danah Al Hattab, Michael P Czubryt
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis

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