Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling

Human Pathology
Chiara CastellaniAnnalisa Angelini

Abstract

The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular remodeling in a model of pressure volume overload leading to right ventricle hypertrophy. Eleven specimens with hypoplastic left heart syndrome were evaluated and compared with 6 normal hearts from subjects matched for age and weight. All underwent Norwood procedure with the right ventricle becoming a systemic one, with pressure and volume overload leading to right ventricle remodeling. Transmural cardiac tissue samples from the right ventricle were analyzed by immunohistochemistry and morphometry. This is the first study to demonstrate that c-Kit-positive progenitor cells and tissue-committed stem cells (CXCR4+/CD45-) are higher in children with systemic right ventricle remodeling. We also show that the localization of cardiac progenitor and recruited CXCR4+ stem cells in the myocardium is site specific in hearts with right ventricle hypertrophy. These cells are mainly scattered in the interstitium of the epicardi...Continue Reading

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Citations

Mar 1, 2012·Basic Research in Cardiology·Stefan RuppDietmar Schranz
Aug 23, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Massimo A PadalinoAnnalisa Angelini
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Oct 13, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Annalisa AngeliniGiorgio Vescovo
Jan 23, 2016·Stem Cells International·Maria E MarketouPanos E Vardas
May 16, 2015·Journal of the American College of Cardiology·Adrián Ruiz-VillalbaJosé M Pérez-Pomares
Apr 8, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Wen-Qun LiYuan-Jian Li
Nov 27, 2014·Frontiers in Pediatrics·Raoul Roman ArnoldMatthias Gorenflo

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