Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Cara L HaymakerHabib Zaghouani

Abstract

The earliest thymic progenitors (ETPs) were recently shown to give rise to both lymphoid and myeloid cells. Whereas the majority of ETPs are derived from IL-7Rα-positive cells and give rise exclusively to T cells, the origin of the myeloid cells remains undefined. In this study, we show both in vitro and in vivo that IL-13Rα1(+) ETPs yield myeloid cells with no potential for maturation into T cells, whereas IL-13Rα1(-) ETPs lack myeloid potential. Moreover, transfer of lineage-negative IL-13Rα1(+) bone marrow stem cells into IL-13Rα1-deficient mice reconstituted thymic IL-13Rα1(+) myeloid ETPs. Myeloid cells or macrophages in the thymus are regarded as phagocytic cells whose function is to clear apoptotic debris generated during T cell development. However, the myeloid cells derived from IL-13Rα1(+) ETPs were found to perform Ag-presenting functions. Thus, IL-13Rα1 defines a new class of myeloid restricted ETPs yielding APCs that could contribute to development of T cells and the control of immunity and autoimmunity.

References

Jul 1, 1988·Science·G J SpangrudeI L Weissman
Oct 1, 1993·The Journal of Experimental Medicine·Y MatsuzakiH Nakauchi
Jan 28, 1994·Cell·H von Boehmer
Jan 1, 1996·Annual Review of Immunology·K Shortman, L Wu
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M ThrosbyM Dardenne
Sep 5, 2001·Current Opinion in Genetics & Development·M KondoI L Weissman
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shoji UeharaPaul E Love
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min LuYoshimoto Katsura
Dec 14, 2002·Immunity·Thomas M Schmitt, Juan Carlos Zúñiga-Pflücker
Jan 7, 2003·Nature Immunology·David AllmanAvinash Bhandoola
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eiji EsashiAtsushi Miyajima
Aug 18, 2004·The Journal of Experimental Medicine·Thomas M SchmittJuan Carlos Zúñiga-Pflücker
Jun 14, 2005·Nature Immunology·Arivazhagan SambandamAvinash Bhandoola
Jun 29, 2005·The Journal of Experimental Medicine·Claudia Benz, Conrad C Bleul
Feb 2, 2006·Immunological Reviews·Thomas M Schmitt, Juan Carlos Zúñiga-Pflücker
Mar 7, 2006·Trends in Immunology·Hiroshi Kawamoto
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kornelia HeinzelConrad C Bleul
Jan 16, 2007·Immunity·Andreas Krueger, Harald von Boehmer
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin A SchwarzAvinash Bhandoola
Feb 17, 2007·Current Opinion in Immunology·Renée de Pooter, Juan Carlos Zúñiga-Pflücker
Jun 22, 2007·Immunity·Hiromi Iwasaki, Koichi Akashi
Jun 22, 2007·Immunity·Li Wu, Yong-Jun Liu
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uwe MüllerGottfried Alber
Apr 11, 2008·Nature·J Jeremiah Bell, Avinash Bhandoola
Apr 11, 2008·Nature·Haruka WadaHiroshi Kawamoto
Sep 3, 2008·The Journal of Experimental Medicine·Hyun-Hee LeeHabib Zaghouani
Mar 10, 2009·Current Opinion in Immunology·Anthony W ChiAvinash Bhandoola
Dec 8, 2009·Blood·Daniel A ZlotoffAvinash Bhandoola
Mar 3, 2010·Annual Review of Immunology·Julie S YuanCynthia J Guidos
Mar 23, 2010·Immunity·Susan M SchlennerHans-Reimer Rodewald

❮ Previous
Next ❯

Citations

Nov 3, 2015·Nature Immunology·Timotheus Y F HalimAndrew N J McKenzie
Jun 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tobechukwu K UkahHabib Zaghouani
Sep 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhasis BarikHabib Zaghouani
Jan 10, 2018·Frontiers in Pharmacology·Krisztina KöröskényiZsuzsa Szondy
Oct 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhasis BarikHabib Zaghouani
Apr 19, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mindy M MillerHabib Zaghouani
Nov 28, 2013·European Journal of Immunology·Mermagya DhakalHabib Zaghouani
May 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine M HoemanHabib Zaghouani
Aug 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhasis BarikHabib Zaghouani
Jun 3, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mermagya DhakalHabib Zaghouani
Sep 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Subhasis BarikHabib Zaghouani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.